৳ 9,090.29/unit
Pack: ৳ 9,090.29
৳ 9,090.29/unit
Pack: ৳ 9,090.29
At a glance
Somatropin is a recombinant human growth hormone used for growth failure due to growth hormone deficiency in children, short stature associated with Noonan syndrome, Turner syndrome, and SGA. It is also indicated for growth hormone deficiency in adults.
Indications
- Pediatric: Growth failure due to endogenous GH deficiency
- Short stature associated with Noonan syndrome
- Short stature associated with Turner syndrome
- Short stature born small for gestational age (SGA)
- Adult: Growth hormone deficiency (adult-onset or childhood-onset)
Pharmacology
Somatropin binds to the GH receptor on target cells, activating intracellular signal transduction. It increases IGF-I production in the liver, which stimulates skeletal growth and protein synthesis. It also directly affects lipolysis and carbohydrate metabolism.
Dosage
Pediatric Dose (SC):
- GH deficiency: 0.024-0.034 mg/kg/day (6-7 times weekly)
- Noonan syndrome: Up to 0.066 mg/kg/day
- Turner syndrome: Up to 0.067 mg/kg/day
- SGA: Up to 0.067 mg/kg/day
Adult Dose (SC):
- Starting: 0.004 mg/kg/day (6 weeks); max 0.016 mg/kg/day
- Or 0.2 mg/day (0.15-0.30 mg/day) starting; increase by 0.1-0.2 mg/day every 1-2 months
Side effects
Common Side Effects:
- Injection site reactions (pain, swelling, redness)
- Headache
- Rash
- Muscle pain, joint stiffness
- Hyperglycemia, glucosuria
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in acute critical illness (heart/abdominal surgery, trauma, respiratory failure)
- Do not use in active neoplasms or diabetic retinopathy
- Do not use in Prader-Willi syndrome with severe obesity or respiratory impairment
- Inform doctor if you have diabetes or thyroid disorders
Overdose effects
No overdose information available; excessive doses may cause hyperglycemia, fluid retention, joint pain; provide symptomatic treatment.
Storage conditions
Store at 2-8°C in a refrigerator; do not freeze; avoid direct light; keep out of reach of children.