Origano DR 360
Rx৳ 90/unit
Pack: ৳ 360
৳ 90/unit
Pack: ৳ 360
At a glance
Mycophenolic Acid is an immunosuppressant used to prevent organ rejection after kidney transplantation. It suppresses the immune system by inhibiting lymphocyte proliferation.
Indications
- Prophylaxis of organ rejection in adult kidney transplant patients
- Prophylaxis of organ rejection in pediatric patients 5 years and older (at least 6 months post kidney transplant)
Pharmacology
Mycophenolic acid is a potent, selective, uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis. MPA has more potent cytostatic effects on lymphocytes than on other cells because T- and B lymphocytes are critically dependent for their proliferation on de novo synthesis of purines.
Dosage
Adult Kidney Transplant: 720 mg twice daily (1440 mg daily dose)
Pediatric Kidney Transplant (5 years+, at least 6 months post-transplant): 400 mg/m² twice daily (max 720 mg twice daily)
BSA 1.19-1.58 m²: 1080 mg/day (3x180 mg or 1x180+1x360 mg tablet twice daily)
BSA >1.58 m²: 1440 mg/day (4x180 mg or 2x360 mg tablet twice daily)
Side effects
Common Side Effects (≥20%):
- Anemia
- Leukopenia
- Constipation
- Diarrhea
- Vomiting
- Dyspepsia
- Urinary tract infection
- CMV infection
- Insomnia
- Postoperative pain
Use in pregnancy
Use in Pregnancy: Mycophenolic Acid is highly unsafe during pregnancy (Category D); definite evidence of severe fetal harm. Completely contraindicated. Discontinue treatment or discontinue nursing.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Can cause embryofetal toxicity
- May increase new or reactive viral infections
- May cause blood dyscrasias (including pure red cell aplasia)
- May cause serious GI tract complications (bleeding, perforations, ulcers)
- May increase risk of lymphomas and other malignancies
- Avoid live vaccines
Overdose effects
Overdose may cause over suppression of immune system and increased risk of infections; symptomatic treatment.
Storage conditions
Store below 30°C; protect from light and moisture; keep out of reach of children.