Oriham10mg

• Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in patients 6 years and older [citation:1][citation:2]

Children & Adolescents (6 years+) - ADHD:

• Body weight ≤70 kg: Initial dose 0.5 mg/kg/day (once daily or divided into 2 doses). After minimum 3 days, increase to target dose 1.2 mg/kg/day. After 2-4 weeks, may increase to maximum 1.4 mg/kg/day or 100 mg/day (whichever is less) [citation:2].
• Body weight >70 kg: Initial dose 40 mg/day (once daily or divided into 2 doses). After minimum 3 days, increase to target dose 80 mg/day. After 2-4 weeks, may increase to maximum 100 mg/day [citation:2].

Adults - ADHD:

• Initial dose: 40 mg/day (once daily or divided into 2 doses). After minimum 3 days, increase to target dose 80 mg/day. After 2-4 weeks, may increase to maximum 100 mg/day [citation:2].

Hepatic Impairment:

• Moderate impairment (Child-Pugh Class B): Reduce dose by 50% [citation:1][citation:2].
• Severe impairment (Child-Pugh Class C): Reduce dose by 75% [citation:1][citation:2].

Renal Impairment: Dose adjustment may be needed in ESRD patients [citation:1][citation:2].

Common Adverse Reactions in Children & Adolescents (≥5% and at least twice placebo):

• Nausea
• Vomiting
• Fatigue
• Decreased appetite
• Abdominal pain
• Somnolence

Common Adverse Reactions in Adults:

• Constipation
• Dry mouth
• Nausea
• Decreased appetite
• Dizziness
• Erectile dysfunction
• Urinary hesitation

Serious Adverse Reactions:

• Suicidal ideation in children and adolescents (0.4% of patients) [citation:1][citation:2]
• Severe liver damage (rare) [citation:10]
• Increased heart rate and blood pressure

Serious Precautions:

• Suicide risk: Atomoxetine increases the risk of suicidal ideation in children and adolescents [citation:1][citation:2]. Close monitoring is required during initiation and dose changes [citation:10].
• Liver damage: Inform your doctor immediately if you experience signs of liver problems (itching, right upper abdominal pain, dark urine, yellow skin/eyes) [citation:10].
• Cardiac risk: Caution in patients with heart problems, heart defects, or high blood pressure [citation:1][citation:2].
• Driving and machinery: Do not drive or operate hazardous machinery until you know how atomoxetine affects you [citation:10].
• Growth and weight monitoring: Monitor height and weight in children during treatment [citation:1].
• Do not stop suddenly: Do not stop taking the medication without talking to your doctor first.