Osiden

Used for the treatment of Paroxysmal Supraventricular Tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome) . Adenosine does not convert atrial flutter, atrial fibrillation, or ventricular tachycardia to normal sinus rhythm .

Adenosine injection slows conduction time through the A-V node, interrupts reentry pathways through the A-V node, and restores normal sinus rhythm in patients with PSVT . It slows conduction at the AV node via A1 receptors and mediates peripheral and coronary vasodilation via A2 receptors . Plasma half-life is <10 seconds, allowing rapid dose titration .

Adult Dose: Pregnancy; heart transplant patients; patients on dipyridamole (lower initial dose of adenosine 0.5-1 mg); atrial fibrillation or flutter with accessory pathway (conduction along anomalous pathway may increase). Lactation: Potential for serious adverse reactions in nursing infants; decision to interrupt nursing after administration of adenosine or not should take into account importance of drug to mother. Renal Dose: Adenosine acts rapidly to slow down conduction through the AV node via the A1 receptors. It also mediates peripheral and coronary vasodilatation by stimulating the A2 receptors. Extremely short plasma half-life (<10 sec) permits dosage titration during IV use every 1-2 min and causes no concern of cumulative effect through repeated dosing.

Common: • Flushing (sense of warmth in the face, ears, neck and trunk) • Dizziness • Lightheadedness • Nausea • Numbness • Tingling • Chest pain

[CONSULT YOUR DOCTOR] Adenosine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[NOT RELEVANT] Not relevant, as Adenosine is intended for use in hospitalised patients. Food and drinks containing caffeine such as chocolate, coffee, and tea must be avoided for at least 12 hours before medicine use. Stop taking medication and inform your doctor immediately if you experience a slow heartbeat, severe chest pain, and very low blood pressure. Inform your doctor if you have a history of fits or problems with your heart. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Adenosine has a half-life of less than 10 seconds, so adverse effects are generally brief and self-limiting. Treatment of prolonged effects is symptomatic. Methylxanthines (caffeine, theophylline) are competitive antagonists of adenosine.

Store in a cool, dry place protected from light. Do not refrigerate, as crystallization may occur. If crystallization occurs, warm the solution to room temperature until the crystals dissolve. The solution must be clear at the time of use. Keep out of reach of children.