Osteonil150mg

• Treatment of osteoporosis in women (especially postmenopausal)
• Prevention of osteoporosis in women (especially postmenopausal)
• Prevention and treatment of osteoporosis in men

Adult Dose (Oral):

• Treatment of osteoporosis: 150 mg film-coated tablet once monthly (on the same date each month)
• Take 60 minutes before first food or drink of the day on empty stomach
• Swallow tablet whole with a full glass of plain water (180-240 ml)
• Take while standing or sitting upright
• Do not lie down for 60 minutes after taking
• Do not chew or suck the tablet

Missed Dose: If remembered, take the next morning (if next scheduled dose is not within 7 days); if within 7 days, wait until next dose; do not take two 150 mg tablets within the same week.

Child Dose: Safety and efficacy not established in patients less than 18 years

Common Side Effects:

• Headache
• Musculoskeletal (bone, muscle or joint) pain
• Dyspepsia
• Heartburn
• Diarrhea
• Abdominal pain
• Nausea
• Dizziness
• Back pain
• Flatulence
• Constipation

Serious: Severe bone, joint and/or muscle pain; osteonecrosis of the jaw; esophagitis, esophageal ulcers or erosions; hypocalcemia

Precautions:

• Treat hypocalcemia and other disturbances of bone and mineral metabolism before starting therapy
• Caution in patients with active upper gastrointestinal problems (Barrett's esophagus, dysphagia, gastritis, duodenitis, ulcers)
• Discontinue and seek medical attention if esophageal irritation symptoms develop
• Risk factors for osteonecrosis of the jaw: cancer, chemotherapy, radiotherapy, corticosteroids, pre-existing dental disease
• Not recommended in severe renal impairment (CrCl <30 ml/min)