৳ 190/unit
Pack: ৳ 1,900
৳ 190/unit
Pack: ৳ 1,900
At a glance
Oteseconazole is an antifungal drug used to reduce the incidence of recurrent vulvovaginal candidiasis (RVVC). It inhibits CYP51 enzyme to disrupt fungal cell membrane integrity.
Indications
- Reduction of incidence of recurrent vulvovaginal candidiasis (RVVC) in females not of reproductive potential
Pharmacology
Oteseconazole inhibits CYP51 (14α demethylase) to prevent ergosterol synthesis required for fungal cell membrane integrity, resulting in accumulation of toxic 14-methylated sterols and fungal cell death.
Dosage
Oteseconazole-only Regimen:
- Day 1: 600 mg (single dose)
- Day 2: 450 mg (single dose)
- Starting Day 14: 150 mg once weekly for 11 weeks
Fluconazole/Oteseconazole Regimen:
- Days 1, 4 & 7: Fluconazole 150 mg
- Days 14-20: Oteseconazole 150 mg once daily for 7 days
- Starting Day 28: 150 mg once weekly for 11 weeks
Side effects
Common Side Effects (>2%):
- Headache
- Nausea
Use in pregnancy
Use in Pregnancy: Oteseconazole is highly unsafe during pregnancy; definite evidence of severe fetal harm. Completely contraindicated.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Contraindicated in females of reproductive potential (embryo-fetal toxicity)
- Contraindicated in pregnant and lactating women
- Drug exposure window of approximately 690 days (5 times half-life) limits mitigation of embryo-fetal toxicity risks
Overdose effects
Limited information on overdose; symptomatic treatment.
Storage conditions
Store at 20-25°C; protect from light when removed from outer carton; keep out of reach of children.