Paclitaxel PhaRes100mg/Vial

• Breast cancer • Non-small cell lung cancer • Pancreatic cancer

Adult Dose: Intravenous Ovarian carcinoma Adult: Primary treatment (in combination with cisplatin or carboplatin): 135 mg/m2 infused over 24 hr followed by cisplatin and repeated at 3 wk intervals. Secondary treatment (as single agent): 135 or 175 mg/m2 infused over 3 hr once every 3 wk. Breast cancer Adult: Adjuvant therapy; 2nd line monotherapy or 1st line treatment with trastuzumab: 175 mg/m2 infused over 3 hr once every 3 wk for 4 courses; when used with trastuzumab, dose should be given the day after the 1st dose of trastuzumab or immediately after subsequent doses if well-tolerated. 1st line with doxorubicin: 220 mg/m2 over 3 hr every 3 wk, dose to be administered 24 hr after doxorubicin. Advanced non-small cell lung cancer Adult: 135 mg/m2 over 24 hr or 175 mg/m2 over 3 hr, followed by cisplatin and repeated at 3 wk intervals. AIDS-related Kaposi's sarcoma Adult: 135 mg/m2 over 3 hr every 3 wk. Alternatively, 100 mg/m2 over 3 hr every 2 wk especially in patients with poor performance status. Hepatic Impairment With solid carcinomas and not Kaposi sarcoma 24-hr infusion AST/ALT 7.5 mg/dL: Do not administer 3-hr infusion AST/ALT 5 x ULN: Do not administer Child Dose: Safety and efficacy not established

Common: • Nausea • Vomiting • Weakness • Low blood platelets • Rash • Upper respiratory tract infection • Urinary tract infection • Bleeding • Anemia (low number of red blood cells) • Flushing (sense of warmth in the face, ears, neck and trunk) • Hair loss • Decreased blood pressure • Peripheral neuropathy (tingling and numbness of feet and hand) • Diarrhea • Decreased white blood cell count (neutrophils)

[UNSAFE] Paclitaxel may cause side effects which could affect your ability to drive. As there is no reason why you cannot continue driving between courses of Paclitaxel but you should remember that this medicine contains some alcohol and it may be unwise to drive Paclitaxel is an anti-cancer medication used for the treatment of breast cancer, pancreatic cancer, and non-small cell lung cancer. It is given as an intravenous (IV) injection into your vein, usually over 1 hour and every three weeks. Do not take Paclitaxel if you are pregnant or breastfeeding. Use reliable methods of contraception to prevent pregnancy while taking this medicine. Your doctor may get regular blood tests done to monitor your blood cells and liver function during treatment with this medicine. Inform your doctor if you notice unexplained bruising or bleeding, sore throat, mouth ulcers, high temperature (fever) or other signs of infection. Talk to your doctor if you have sudden weight gain or if you have swelling in your arms and legs that doesn't go away.