৳ 11/unit
Pack: ৳ 110
৳ 11/unit
Pack: ৳ 110
At a glance
Paliperidone is an atypical antipsychotic used for schizophrenia and schizoaffective disorder. It blocks dopamine D2 and serotonin 5HT2A receptors to improve mood, thoughts and behavior.
Indications
- Schizophrenia (acute treatment and recurrence prevention)
- Schizoaffective disorder (monotherapy or with antidepressants/mood stabilizers)
Pharmacology
Paliperidone blocks dopamine D2 and serotonin 5HT2A receptors to control psychosis symptoms. It also blocks α1, α2 adrenergic and H1 histaminergic receptors.
Dosage
Adult Dose (Oral):
- Schizophrenia: 6 mg/day (initial); increase by 3 mg/day (at intervals >5 days); max 12 mg/day
- Schizoaffective disorder: 6 mg/day (initial); 3-12 mg/day; max 12 mg/day
Pediatric Dose (>51 kg): 3 mg/day (initial); 3-12 mg/day; max 12 mg/day
Pediatric Dose (<51 kg): 3 mg/day (initial); 3-6 mg/day; max 6 mg/day
Side effects
Common Side Effects:
- Tachycardia
- Akathisia
- Somnolence
- Tremor
- Dystonia
- Cogwheel rigidity
- Anxiety
- Weight increased
- Dyspepsia
- Constipation
- Nasopharyngitis
- Nystagmus
Use in pregnancy
Use in Pregnancy: Paliperidone may be unsafe during pregnancy; animal studies show evidence of fetal harm.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not stop suddenly (may worsen symptoms)
- Caution in CV disease, QT prolongation, NMS, tardive dyskinesia, hyperglycemia, dyslipidemia, obesity, hyperprolactinemia, leukopenia, neutropenia, agranulocytosis, seizures
- Caution while driving
- Avoid alcohol
- Monitor blood glucose regularly
Overdose effects
Limited information on overdose; no specific antidote; symptomatic supportive measures.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.