Pantex 20

Peptic ulcer disease, H. pylori infection, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Oesophagitis, Acid-related dyspepsia, NSAID-associated ulceration, ulcer resistant to H2 receptor antagonists, Gastrointestinal (GI) bleeding from stress, Prophylaxis for acid aspiration syndrome during induction of anaesthesia

Adult Dose: Erosive Esophagitis Associated With GERD Treatment: 40 mg PO qDay for 8-16 weeks Maintenance of healing: 40 mg PO qDay Alternatively, 40 mg IV qDay for 7-10 days Short-term Treatment of GERD Oral therapy inappropriate or not possible: 40 mg IV infusion over 15 minutes qDay for 7-10 days; switch to PO once patient able to swallow Zollinger-Ellison Syndrome 40 mg PO qDay; up to 240 mg/day administered in some patients 80 mg IV infusion q8-12hr up to 7 days; switch to PO once patient able to swallow Peptic Ulcer Disease Duodenal ulcer: 40 mg PO qDay for 2-4 weeks Gastric ulcer: 40 mg PO qDay for 4-8 weeks Elderly: No dosage adjustment needed. Hepatic impairment: Max: 20 mg/day or 40 mg on alternate days. Child Dose: Erosive Esophagitis Associated With GERD 5 years 15 kg to <40 kg: 20 mg PO qDay for up to 8 weeks 40 kg or greater: 40 mg PO qDay for up to 8 weeks Renal Dose: Renal impairment: No dosage adjustment needed.

1-10% Headache (>4%),Abdominal pain (4%),Facial edema (4%),Photosensitivity (<2%) Frequency Not Defined Angioedema,Atrophic gastritis,Anterior ischemic optic neuropathy,Hepatocellular damage leading to hepatic failure,Interstitial nephritis,Pancreatitis,Pancytopenia,Rhabdomyolysis,Risk of anaphylaxis,Stevens-Johnson syndrome,Fatal toxic epidermal necrolysis,Erythema multiforme

Gastric malignancy should be ruled out. Consider Zn++ supplementation during IV therapy in patients who are prone to Zn++ deficiency. Pregnancy. Monitoring Parameters Monitor Mg levels prior to initiation and periodically during prolonged use. Lactation Risk Summary Pantoprazole has been detected in breast milk of a nursing mother after a single 40 mg oral dose of pantoprazole. There were no effects on the breastfed infant. There are no data on pantoprazole effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for PROTONIX and any potential adverse effects on the breastfed child from pantoprazole or from the underlying maternal condition.