৳ 6.04/unit
Pack: ৳ 60.40
৳ 6.04/unit
Pack: ৳ 60.40
At a glance
Pramipexol is used for the treatment of Parkinson's disease and restless leg syndrome. It acts as a dopamine receptor agonist and alleviates Parkinsonian motor deficits by stimulating dopamine receptors in the striatum of the brain.
Indications
- Parkinson's disease (alone or as adjunct to levodopa)
- Moderate to severe restless legs syndrome
Pharmacology
Pramipexole is a non-ergot dopamine agonist with specificity for the D2 subfamily of dopamine receptors, with preference for the D3 receptor subtype. It stimulates dopamine receptors in the striatum of the brain to alleviate Parkinsonian motor deficits.
Dosage
Adult Dose (Oral):
- Parkinson's disease: Initial 88 mcg three times daily; double every 5-7 days up to 350 mcg three times daily; further increase by 180 mcg three times daily at weekly intervals; max 3.3 mg/day in 3 divided doses
- Restless legs syndrome: Initial 88 mcg once daily (2-3 hours before bedtime); double every 4-7 days up to 350 mcg daily; max 540 mcg daily
- Renal impairment: CrCl 30-50 mL/min: 0.125 mg twice daily initially; max 0.75 mg TID; CrCl 15-29 mL/min: 0.125 mg/day; max 1.5 mg/day
Side effects
Common Side Effects:
- Dizziness
- Sleepiness
- Nausea
- Dry mouth
- Fatigue
- Hallucinations
- Constipation
- Peripheral edema
- Dyskinesia
- Hypotension
- Abnormal dreams
- Confusion
- Headache
- Hyperkinesia
- Increased eating
- Insomnia
- Libido disorders
- Paranoia
- Pathological gambling
- Hypersexuality
- Weight increase
- Sudden onset of sleep
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Inform doctor if hallucinations or compulsive behaviors (binge eating, gambling, spending, sexual urges) occur
- May cause sudden drop in blood pressure when changing positions; rise slowly
- Caution in psychotic disorders, severe cardiovascular disease, renal impairment
- Regular ophthalmologic monitoring recommended
Overdose effects
Overdose: Nausea, vomiting, hyperkinesia, hallucinations, agitation, hypotension; no established antidote; gastric lavage, IV fluids, activated charcoal, EKG monitoring.
Storage conditions
Store in a cool and dry place; protect from light.