Pedryl10mg/5ml
Rx- Generic:
- Diphenhydramine Hydrochloride
- Company:
- Oyster Pharmaceuticals Ltd.
- Dosage form:
- Syrup
- Pack size:
- 100ml bot
৳ 20/unit
Pack: ৳ 20
At a glance
Diphenhydramine Hydrochloride — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Diphenhydramine Hydrochloride is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching and other symptoms of allergies and common cold. It is also used to suppress coughs, to treat motion sickness and to induce sleep. Diphenhydramine Hydrochloride should be taken before a meal or at bedtime, but take it at the same time every day to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. In case, you have missed any doses than it is better to take the next dose as soon as you remember it. However, you should never take a double dose. Dizziness or drowsiness is the most common side effect of this medicine. Avoid driving or attention-seeking activity. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. In some cases, it may cause dryness of mouth, so it is advised to drink more water, always carry sugar candy or maintain oral hygiene. Before taking this medicine, let your doctor know if you have glaucoma or have any gastro related issues or have asthma. Inform your doctor if you are pregnant, or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Generally, it is advised to avoid alcohol while on treatment. Diphenhydramine Hydrochloride is an antihistaminic medication. It blocks the action of certain chemical messengers that are responsible for inflammation, congestion, itching, and other allergic reactions.
Indications
• Motion sickness • Insomnia • Nasal allergy symptoms
Mechanism of action
Diphenhydramine blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and respiratory tract. It also causes sedation and has some anticholinergic action.
Dosage
Adult Dose: Oral Allergic conditions; Treatment and prophylaxis of motion sickness Adult: 25-50 mg 3-4 times daily. For prevention of motion sickness, admin 30 min before exposure to motion. Max: 300 mg daily. Parkinson's disease Adult: Initially, 25 mg tid, may increase to 50 mg 4 times daily if necessary. Short-term management of insomnia Adult: 50 mg 30 min before bedtime as needed. Hepatic impairment: No dosage adjustment needed. Child Dose: Allergic Reaction 2-6 years: 6.25 mg q4-6hr; not to exceed 37.5 mg/day 6-12 years: 12.5-25 mg PO q4-6hr; not to exceed 150 mg/day >12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day Occasional Insomnia >12 years: 50 mg PO 30 minutes before bedtime Cough 12 years: 25-50 mg PO q4-6hr; not to exceed 300 mg/day Motion Sickness Administer 30 min before motion 12.5-25 mg PO q6-8hr or 150 mg/m² ; not to exceed 300 mg/day Renal Dose: Renal impairment: No dosage adjustment needed.
Administration
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Diphenhydramine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time.
Missed dose
If you miss a dose of Diphenhydramine Hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common: • Dizziness • Drowsiness • Dryness in mouth
Precautions & warnings
[UNSAFE] Diphenhydramine Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Avoid driving or operating dangerous machinery as it may decrease alertness. Avoid consuming alcohol when taking the Diphenhydramine Hydrochloride, as it may cause excessive sleepiness or drowsiness.
Contraindications
Hypersensitivity ; neonates, lactation.
Drug interactions
Masks ototoxicity produced by aminoglycosides. Increases gastric degradation of levodopa and decreases its absorption by reduction of gastric emptying. Antagonises therapeutic effects of cholinergic agents e.g. tacrine, donezepil and neuroleptics. Valerian, St. John's wort, Kava Kava and gotu kola may increase CNS depression. Potentially Fatal: Potentiates CNS depression with alcohol, barbiturates, analgesics, sedatives and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and TCAs.
Food interactions
[UNSAFE] Diphenhydramine Hydrochloride may cause excessive drowsiness with alcohol.
Use in pregnancy
[SAFE IF PRESCRIBED] Diphenhydramine Hydrochloride is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Use in lactation
[SAFE IF PRESCRIBED] Diphenhydramine Hydrochloride is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Larger doses or prolonged use of Diphenhydramine Hydrochloride may cause sleepiness and other effects in the baby
Renal / hepatic impairment
[SAFE IF PRESCRIBED] Diphenhydramine Hydrochloride is safe to use in patients with kidney disease. No dose adjustment of Diphenhydramine Hydrochloride is recommended. However, talk to your doctor if you have any underlying kidney disease. [CONSULT YOUR DOCTOR] There is limited information available on the use of Diphenhydramine Hydrochloride in patients with liver disease. Please consult your doctor.
Common questions
difficulty in climbing steps. can't climb many steps. it is easy to get down. some say it is muscular distropy. now a days it is getting dif Hi PATIENT think you should consult with any panchkarma centre for ayurvedic treatment . Stomach acidity after eating any food , loss of appetite insomnia also u have psychiatric problem. irritable bowel syndrome take tablet amitryptaline 25mg hs for 14 days To feel giddy sometimes during driving Take tab avomine for motion sickness I feel uneasy during traveling in car i feel vomiting tendency You may have motion sickness. Please see an ENT specialist. Is there any treatment for motion sickness u can take tab stemetil before travlling Best and safe medicine for motion sickness Take Ondem 4 mg before u travelOr pheneragan 25 mg if only Ondem doesn't work , because phenargan can make u sleep Any tips for motion sickness for lactating mother Syrup vomiteb 2 spoon thrice before meal .20 ml triphala juice at night. Body temperature is high but no fever symptoms during night i can't able to deep sleep For insomnia consult a psychiatrist