৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Pemafibrate is a selective PPARα modulator used as adjunctive therapy to diet to reduce TG in patients with dyslipidemia, including familial hyperlipidemia.
Indications
- Dyslipidemia (hypertriglyceridemia)
- Familial hyperlipidemia
Pharmacology
Pemafibrate is a selective PPARα modulator containing benzoxazole and phenoxyalkyl side-chains along with a fibric acid group. It binds tightly to the PPARα receptor and provides maximum activation. It is over 2,500-fold more potent than conventional fibrates with high selectivity.
Dosage
Adult Dose (Oral):
- Usual dose: 0.1 mg twice daily
- Dose may be individualized according to patient's age and symptoms
- Renal impairment (eGFR <30 mL/min/1.73m²): Lower starting dose or prolonged dosing intervals; max 0.2 mg/day
Pediatric Dose: Safety not established.
Side effects
Side Effects:
- Gastro-intestinal disorders (nausea, diarrhea, abdominal pain)
- Jaundice
- Skin rashes
- Gallstones
- Myotoxicity
Use in pregnancy
Use in Pregnancy: Contraindicated in pregnant or possibly pregnant women; safety not established.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Rhabdomyolysis risk (with statins); suspect muscle toxicity if myalgia, myositis, muscle cramps, weakness, or CK >5 x ULN; discontinue treatment
- Caution in hepatic disorders; monitor liver function
- Caution in history of cholelithiasis
- Monitor LDL-cholesterol levels
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Do not store above 30°C; keep away from light; keep out of reach of children.