৳ 100/unit
Pack: ৳ 100
৳ 100/unit
Pack: ৳ 100
At a glance
Mesalazine [5-aminosalicylic acid] is an anti-inflammatory medicine used for inflammatory bowel disease (IBD), particularly ulcerative colitis and Crohn's disease. It reduces inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
Indications
- Inflammatory bowel disease (IBD) - ulcerative colitis and Crohn's disease
- Mild to moderately active ulcerative colitis - treatment and maintenance of remission
- Crohn's disease - maintenance of remission
Pharmacology
Mesalamine blocks cyclooxygenase and inhibits prostaglandin production in the colon to reduce inflammation. It reduces mucosal production of arachidonic acid metabolites.
Dosage
Adult Dose (Oral):
- Ulcerative colitis (active): Up to 4 g/day (once daily or in 2-4 divided doses)
- Ulcerative colitis (maintenance): 2 g/day (once daily)
Children (6-18 years):
- Active: 30-50 mg/kg/day in divided doses; max 75 mg/kg/day (up to 4 g/day)
- Maintenance: 15-30 mg/kg/day in divided doses; max 2 g/day
- Children up to 40 kg: half adult dose; above 40 kg: adult dose
Side effects
Common Side Effects:
- Stomach upset
- Nausea
- Diarrhea
- Headache
- Vomiting
- Abdominal pain
- Skin rash
Use in pregnancy
Use in Pregnancy: Mesalazine crosses the placenta and may cause fetal harm; use only if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Pyloric stenosis may cause delayed gastric retention
- Caution in renal dysfunction (nephropathy, interstitial nephritis)
- Caution in liver disease
- Consult doctor during pregnancy and lactation
- Monitor blood cell counts in patients 65 years and older
Overdose effects
No specific antidote for overdose; symptomatic and supportive treatment (prevent GI absorption, fluid/electrolyte balance, renal function).
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.