Pentothal Sodium

Thiopental Sodium is a prescription medicine used for producing general anesthesia. It is also used as truth serum because it alters certain functions in the brain and make the person incapable of lying. It has now been used to reduce intracranial pressure also. Thiopental Sodium is given as an injection in hospital settings under the supervision of a healthcare professional. It is important to provide medical history and inform your doctor if you are suffering from cardiovascular disease, asthma or myasthenia gravis as special care is needed in administering this medicine to such patients. Some common side effects of this medicine are skin rash or pain at the site of injection, nausea, vomiting, diarrhea, and vertigo. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus. You should avoid drinking alcohol or taking other medications that cause drowsiness after taking this medicine as it may result in serious effects. Ensure that you practice additional pregnancy control methods as this medicine may decrease the effectiveness of birth control pills. Thiopental Sodium is a general anaesthetic. It works by causing reversible loss of consciousness to allow surgery without pain and distress.

• Anesthesia

Thiopental sodium, a short-acting barbiturate anaesthetic, is a CNS depressant inducing hypnosis and anaesthesia but not analgesia. It has also been used in the control of refractory tonic-clonic status epilepticus and to reduce increased intracranial pressure in neurosurgical patients.

Adult Dose: Intravenous Induction of anaesthesia Adult: 100-150 mg of a 2.5 or 5% solution injected over 10-15 sec repeated every 30-60 sec according to response or as a continuous infusion of a 0.2 or 0.4% solution. Max: 500mg. Max in pregnancy: 250mg. Status epilepticus Adult: In conjunction with assisted ventilation: 75-125 mg as a 2.5% solution. Reduction of raised intracranial pressure Adult: Intermittent bolus inj of 1.5-3.5 mg/kg, if adequate ventilation is provided. Elderly: Dose reduction may be needed. Hepatic impairment: Dose reduction may be needed. Child Dose: Intravenous Induction of anaesthesia Child: 2-7 mg/kg over 10-15 seconds; repeated after 1 minute if needed.. Status epilepticus Child: 5 mg/kg by slow IV inj followed by, neonates: continuous iv infusion of 2.5 mg/kg/hr; >1 month: 2-8 mg/kg/hr. Adjust infusion dose according to response. Reduction of raised intracranial pressure Child: 3 mth-15 yr: initial 5-10-mg/kg IV followed by a continuous IV infusion at 1-4 mg/kg/hr. Renal Dose: Renal impairment: Dose reduction may be needed.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Injection site reactions (pain, swelling, redness) • Drowsiness • Skin rash • Nausea • Vomiting • Diarrhea • Vertigo

[UNSAFE] Thiopental Sodium may cause side effects which could affect your ability to drive. Thiopental Sodium is used to facilitate surgery without pain and distress. It is given as an injection into veins under the supervision of a doctor. It can cause severe drowsiness lasting for several hours. Do not drive or do anything that requires alertness for at least 24 hours. Inform your doctor if you have liver disease, thyroid disorder, severe heart disease, severe low blood pressure or a severe breathing disorder. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Thiopental Sodium for Injection is contraindicated in patients with severe respiratory embarrassment, hypersensitivity to barbiturates, status asthmaticus, variegate or acute intermittent porphyria, and inflammatory conditions of the mouth, jaw, and neck and in the absence of suitable veins for intravenous administration. Thiopental Sodium for Injection is also relatively contraindicated in severe cardiovascular disease, hypotension or shock, and conditions in which the hypnotic effect may be prolonged or potentiated, i.e. excessive premedication, Addison's disease, hepatic or renal dysfunction, myxedema, increased blood urea, severe anemia and myasthenia gravis.

Possible increase in difficulty in producing anaesthesia in patients taking alcohol or CNS depressants. Additive action with other CNS depressants including sedatives, hypnotics, nitrous oxide or alcohol. Increased hypotension and excitatory effects with phenothiazine antipsychotics. Increased hypnotic effect with antipsychotic. Decreased requirement of thiopental sodium with metoclopramide, sulfisoxazole, aspirin, meprobamate, probenecid and other highly protein bound drugs. Potentially Fatal: Increased resp depression with opioids.

[UNSAFE] It is unsafe to consume alcohol with Thiopental Sodium.

[CONSULT YOUR DOCTOR] Thiopental Sodium may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Thiopental Sodium is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CAUTION] Thiopental Sodium should be used with caution in patients with kidney disease. Dose adjustment of Thiopental Sodium may be needed. Please consult your doctor. [CAUTION] Thiopental Sodium should be used with caution in patients with liver disease. Dose adjustment of Thiopental Sodium may be needed. Please consult your doctor.

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