৳ 35.20/unit
Pack: ৳ 35.20
৳ 35.20/unit
Pack: ৳ 35.20
At a glance
Procyclidine Hydrochloride is an antimuscarinic antiparkinsonian agent used for adjunctive treatment of all forms of parkinsonian syndrome and for controlling troublesome extrapyramidal symptoms including pseudoparkinsonian, acute dystonic reactions, and akathisia induced by neuroleptic drugs such as phenothiazine derivatives.
Indications
- Parkinsonian syndrome (idiopathic, postencephalitic, and arteriosclerotic)
- Neuroleptic-induced extrapyramidal symptoms (pseudoparkinsonian, acute dystonic reactions, akathisia)
Pharmacology
Procyclidine hydrochloride is an antimuscarinic agent that corrects the relative cholinergic excess in parkinsonian states due to dopamine deficiency. It blocks excess acetylcholine at cerebral synapses and exhibits direct antispasmodic effect on smooth muscle.
Dosage
Adult Dose (Oral):
- Parkinsonism and drug-induced extrapyramidal syndrome: Initial 2.5 mg three times daily; increase by 2.5-5 mg every 2-3 days if needed; maintenance 10-30 mg/day in 3-4 divided doses; up to 60 mg/day in some cases
- Elderly: Lower doses required
Parenteral Dose:
- Parkinsonism/drug-induced extrapyramidal syndrome (emergency): IV: 5-10 mg; IM: 5-10 mg single dose, repeat after 20 min if needed, max 20 mg/day
Pediatric Dose (Oral):
- Dystonia (7-12 years): 1.25 mg three times daily; (12-18 years): 2.5 mg three times daily
- Emergency (IM/IV): <2 years: 0.5-2 mg; 2-10 years: 2-5 mg; 10-18 years: 5-10 mg
Side effects
Common Side Effects:
- Dry mouth (most common)
- Mydriasis
- Blurred vision
- Nausea
- Vomiting
- Epigastric distress
- Constipation
- Dizziness
- Urinary retention
- High doses: Vertigo, confusion, hallucinations
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Caution in glaucoma, prostatic hypertrophy, urinary retention, cardiovascular disease
- Do not stop abruptly (rebound Parkinsonism symptoms may occur)
- Psychotic patients may experience precipitation of psychotic episode
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Protect from light and moisture, store below 25°C; keep out of reach of children.