৳ 120/unit
Pack: ৳ 120
৳ 120/unit
Pack: ৳ 120
At a glance
Bismuth Subsalicylate is a medicine used in the treatment of diarrhea, nausea, heartburn, indigestion, and upset stomach. It works through antimicrobial, anti-inflammatory, and antisecretory actions.
Indications
- Upset stomach
- Indigestion
- Heartburn
- Nausea
- Diarrhea
Pharmacology
Bismuth Subsalicylate has antacid, antidiarrheal, and anti-inflammatory actions. It coats ulcer surfaces, protects from acid and pepsin, stimulates mucus and bicarbonate secretion, and reacts with HCl to reduce it. In diarrhea, it stimulates fluid and electrolyte absorption and binds with E.coli toxin. Hydrolyzed to salicylic acid, it inhibits prostaglandin G/H synthase ½, reducing inflammation.
Dosage
Adults (>16 years): 30 ml (in dosing cup or 6 spoonfuls) 3-4 times daily, 30 minutes before meals. Repeat every ½ to 1 hour if needed. Maximum 8 doses in 24 hours.
Children (10-14 years): 15 ml (3 teaspoons)
Children (5-9 years): 7.5 ml (1.5 teaspoons)
Children (3-4 years): 5 ml (1 teaspoon)
Under 3 years: Ask a doctor.
Note: Do not use for more than 2 days. Do not use if symptoms are severe or persist for more than 2 days.
Side effects
>10%: Nausea (12%)
1-10%: Diarrhea (7%), Abdominal pain (7%), Melena (3%), Upper respiratory tract infection (2%), Constipation (2%), Anorexia (2%), Vomiting (2%), Asthenia (2%), Discolored tongue (2%), Headache (2%), Dyspepsia (2%), Dizziness (2%), Stool abnormality (1%), Duodenal ulcer (1%), Sinusitis (1%), Taste perversion (1%), Flatulence (1%), GI hemorrhage (1%), Pain (1%), Insomnia (1%), Anal discomfort (1%), Paresthesia (1%)
Frequency Not Defined: Anxiety, Confusion, Depression, Tinnitus, Weakness, Gray-black stool, Impaction, Muscle spasm, Neurotoxicity (rare)
Use in pregnancy
Pregnancy category: C; D in 3rd trimester. Adequate data not available. Animal studies insufficient. Potential risk for humans unknown. Consult your doctor before use during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause black tongue and/or black stool (common and harmless).
- Do not take with aspirin or other salicylates.
- Caution should be exercised in patients taking anticoagulants (blood thinners), diabetes medications, or gout/arthritis medications.
- Do not use for more than 2 days.
- Do not use if symptoms are severe or persist for more than 2 days.
- Do not exceed the recommended dose.
Overdose effects
Bismuth intoxication: May present as acute encephalopathy (confusion, myoclonic movements, tremor, dysarthria, walking and standing disorders), gastrointestinal disturbances, skin reactions, discoloration of mucous membranes, and renal dysfunction (acute tubular necrosis). Treatment includes gastric lavage, purgation, and hydration. Chelating agents and hemodialysis may be necessary.
Salicylate intoxication: Dizziness, tinnitus, sweating, nausea, headache. Discontinue use if symptoms occur and consult a doctor.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach and sight of children.