Platinex1mg/ml

• Metastatic Testicular Tumors
• Metastatic Ovarian Tumors
• Advanced Bladder Cancer
• Non-Small Cell Lung Carcinoma
• Cervical Cancer

Metastatic Testicular Tumors: 20 mg/m²/day IV for 5 days/cycle (in combination with other chemotherapeutic agents).

Advanced Bladder Cancer: 50-70 mg/m² IV every 3-4 weeks.

Metastatic Ovarian Carcinoma: 75-100 mg/m² IV every 4 weeks (in combination with cyclophosphamide).

Non-Small Cell Lung Carcinoma: 75 mg/m² (in combination with Paclitaxel) every 3 weeks.

Renal Dose: CrCl 10-50 mL/min: Decrease dose 50%; CrCl <10 mL/min: Contraindicated.

Common Side Effects:

• Injection site reactions (pain, swelling, redness)
• Increased risk of infection
• Ear disorders (hearing loss, tinnitus)
• Vomiting
• Nausea
• Decreased blood cells (red cells, white cells, and platelets)
• Renal impairment (kidney damage)
• Peripheral neuropathy (tingling and numbness of feet and hand)
• Electrolyte disturbances (hypomagnesemia, hypocalcemia, hypokalemia)

Serious Side Effects: Ototoxicity, nephrotoxicity, neurotoxicity, severe bone marrow suppression.

• [UNSAFE] Cisplatin may cause side effects which could affect your ability to drive. Sleepiness and/or vomiting could affect your ability to drive.
• Renal function: Monitor creatinine, BUN, and electrolytes. Hydrate with 1-2 L fluid before treatment and ensure adequate hydration.
• Bone marrow function: Monitor complete blood counts frequently.
• Hearing function: Perform audiometry prior to therapy and repeat when symptoms occur.
• CNS functions: Neurologic examination warranted; discontinue if neurotoxic signs appear.
• Contraindicated during pregnancy and lactation.