৳ 12.08/unit
Pack: ৳ 12.08
৳ 12.08/unit
Pack: ৳ 12.08
At a glance
Aspirin + Clopidogrel is a combination antiplatelet medicine used to prevent heart attack and stroke by reducing the formation of harmful blood clots in blood vessels.
Indications
- Acute Coronary Syndrome (ACS) - non-ST-elevation ACS (UA/NSTEMI) and ST-elevation ACS (STEMI)
- Recent Myocardial Infarction (MI)
- Recent Stroke
- Established Peripheral Arterial Disease (PAD)
Pharmacology
Clopidogrel is a prodrug. It is converted to an active metabolite that irreversibly binds to the P2Y12 class of ADP receptors on platelets, inhibiting platelet activation and aggregation. At 75 mg daily, inhibition reaches steady state between Day 3 and Day 7.
Aspirin irreversibly inhibits platelet cyclooxygenase, reducing thromboxane A2 production - a powerful inducer of platelet aggregation and vasoconstriction.
This combination inhibits platelet aggregation through two distinct pathways, providing enhanced antithrombotic effect.
Dosage
Adult:
- Maintenance: Clopidogrel 75 mg + Aspirin 75-150 mg (usually 75 mg) once daily
- ACS: Clopidogrel 300 mg loading dose, then 75 mg daily + Aspirin 75-325 mg daily
- Elderly & renal patients: No dose adjustment needed
Side effects
- Abdominal pain
- Diarrhea
- Bruise
- Nosebleeds
- Gastrointestinal bleeding
- Increased bleeding tendency
- Indigestion
Rare: Thrombotic Thrombocytopenic Purpura (TTP)
Use in pregnancy
[CONSULT YOUR DOCTOR] Use in 1st and 2nd trimester only if clearly needed. Contraindicated in 3rd trimester.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
Serious Precautions:
- May prolong bleeding time - be careful while shaving, cutting nails, using sharp objects
- Discontinue 7-10 days before elective surgery
- Contraindicated in active peptic ulcer, haemophilia, haemorrhagic disorders, severe renal/hepatic impairment
- Do not use in children under 12 years (Reye's syndrome risk)
- Contraindicated in 3rd trimester of pregnancy
- Caution in asthma, allergies, nasal polyps
- Avoid alcohol consumption
Overdose effects
Clopidogrel: Overdose may lead to bleeding complications. Platelet transfusion may be needed.
Aspirin: Moderate intoxication: dizziness, tinnitus, confusion, GI symptoms. Severe: respiratory alkalosis/acidosis, metabolic acidosis, hyperthermia, dehydration. Haemodialysis may be required.
Storage conditions
Store below 30°C, in a cool and dry place, protected from light and moisture. Keep out of reach of children.