Pofol IV Injection10mg/ml

• Induction and maintenance of general anesthesia
• Sedation during intensive care
• Sedation for surgical and diagnostic procedures

Adult Dose (IV):

• General anesthesia induction: 40 mg every 10 seconds; usual dose 1.5-2.5 mg/kg
• Maintenance: 4-12 mg/kg/hr OR intermittent bolus 20-50 mg
• Elderly/neurosurgical: 20 mg every 10 seconds; maintenance 3-6 mg/kg/hr; dose 1-1.5 mg/kg
• Sedation (diagnostic/surgical): 6-9 mg/kg/hr for 3-5 min OR 0.5-1 mg/kg slow IV over 1-5 min; maintenance 1.5-4.5 mg/kg/hr
• Ventilated patients: 0.3-4 mg/kg/hr

Pediatric Dose (IV):

• Anesthesia induction (3-16 years): 2.5-3.5 mg/kg over 20-30 sec
• Maintenance (2 months-16 years): 0.125-0.3 mg/kg/min
• Under 3 years: Not recommended

Side Effects:

• Injection site pain
• Hypotension
• Transient apnea
• Headache
• Nausea
• Vomiting
• Bradycardia
• Seizures (rare)
• Hypersensitivity reactions
• Green or reddish-brown urine discoloration (with prolonged administration)

• Should only be given by specialists in anesthesiology or under their supervision
• Resuscitation facilities must be available
• Caution in cardiac, respiratory, renal, or hepatic insufficiency
• Caution in hypovolemic patients
• May cause convulsions in epileptic patients
• Do not drive or operate machinery after administration