Polymycin

• Conjunctivitis
• Keratitis
• Keratoconjunctivitis
• Blepharitis
• Blepharoconjunctivitis
• Superficial bacterial infections
• Corneal ulcer

Neomycin is bactericidal for many gram-positive and gram-negative organisms. It is an aminoglycoside antibiotic which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code. Polymyxin B is bactericidal for a variety of gram-negative organisms. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane. Gramicidin is bactericidal for a variety of gram-positive organisms. It increases the permeability of the bacterial cell membrane to inorganic cations by forming a network of channels through the normal lipid bilayer of the membrane.

Adult & Child Dose:

• 1-2 drops into the affected eye every 4 hours
• For 7 to 10 days
• In severe infections, may be increased to 2 drops every hour

Common Side Effects:

• Allergic reactions - itching, swelling, conjunctival erythema
• Local irritation
• Anaphylaxis (rare)

Use in Pregnancy: Pregnancy Category C. Use only if clearly needed.

Precautions:

• Prolonged use may result in overgrowth of non-susceptible organisms including fungi
• Bacterial resistance may develop
• If purulent discharge, inflammation or pain becomes aggravated, discontinue and consult doctor
• Allergic cross-reactions may occur (kanamycin, paromomycin, streptomycin, gentamicin)

Overdose: Overdose is unlikely when used as directed. Excessive use may cause eye irritation.

Storage: Store in a cool and dry place.