Ponatinix 45
Rx- Generic:
- Ponatinib Hydrochloride
- Company:
- Beacon Pharmaceuticals PLC
- Dosage form:
- Tablet
- Pack size:
- Box (30 Tablet)
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৳ 1,937.60/unit
Pack: ৳ 58,128
At a glance
Ponatinib Hydrochloride is a kinase inhibitor used for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), particularly in patients resistant or intolerant to dasatinib or nilotinib, and those with the T315I mutation.
Indications
- Chronic Myeloid Leukemia (CML) - chronic, accelerated, or blast phase (dasatinib/nilotinib-resistant or intolerant, or T315I mutation)
- Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) - dasatinib-resistant or intolerant, or T315I mutation
Dosage
Adult Dose (Oral):
- Recommended starting dose: 45 mg once daily
- CP-CML patients with major cytogenetic response: Consider dose reduction to 15 mg
- With strong CYP3A inhibitors: Consider starting dose 30 mg
- Renal impairment (CrCl >50 mL/min): No dose adjustment; CrCl <50 mL/min or ESRD: Caution
- Hepatic impairment: Caution
Side effects
Serious Adverse Reactions (>2%):
- Pneumonia
- Pancreatitis
- Abdominal pain
- Atrial fibrillation
- Pyrexia
- Myocardial infarction
- Peripheral arterial occlusive disease
- Anemia
- Angina pectoris
- Decreased platelets
- Febrile neutropenia
- Hypertension
- Coronary artery disease
- Congestive heart failure
- Cerebrovascular accident
- Sepsis
- Cellulitis
- Acute kidney injury
- Urinary tract infection
- Increased lipase
Precautions & warnings
- Myelosuppression: Thrombocytopenia, neutropenia, anemia; CBC every 2 weeks for first 3 months, then monthly
- Arterial occlusion (myocardial infarction, stroke, retinal arterial occlusion): Manage cardiovascular risk; interrupt if occurs
- Venous thromboembolism: Monitor; interrupt if thromboembolism occurs
- Hypertension: Monitor and manage blood pressure at each clinic visit
- Congestive heart failure: Monitor for symptoms; consider discontinuation if serious
- Hepatotoxicity: Monitor liver function tests
- Severe hemorrhage: Interrupt and evaluate
- Hepatitis B reactivation: Test before initiating treatment
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.