৳ 12/unit
Pack: ৳ 120
৳ 12/unit
Pack: ৳ 120
At a glance
Propantheline Bromide is a quaternary ammonium antimuscarinic with antisecretory and antispasmodic effects. It is used for adjunctive therapy in peptic ulcer, relief of gastritis symptoms, symptomatic treatment of diarrhea related irritable bowel syndrome, urinary incontinence, control of salivation and enuresis, improvement of lactose intolerance, and prevention of excessive sweating (hyperhidrosis).
Indications
- Adjunctive therapy in peptic ulcer (gastric and duodenal)
- Relief of gastritis symptoms
- Symptomatic treatment of diarrhea related irritable bowel syndrome
- Urinary incontinence
- Control of salivation and enuresis
- Improvement of lactose intolerance
- Prevention of excessive sweating (hyperhidrosis)
Pharmacology
Propantheline Bromide acts through anticholinergic effect at acetylcholine receptors and direct effect on smooth muscle. It reduces acetylcholine effects on smooth muscle, inhibits gastrointestinal motility, decreases gastric acid secretion, and reduces other secretions (pancreatic juice, sweat, saliva).
Dosage
Adult Dose (Oral):
- Peptic ulcer/GI spasm: 15 mg three times daily (30 min before meals) + 30 mg at bedtime; up to 120 mg daily
- Elderly: 7.5 mg three times daily; max 30 mg three times daily
- Urinary incontinence/Enuresis/Hyperhidrosis: 15-30 mg 2-3 times daily
Pediatric Dose (Oral):
- GI spasm (1 month-12 years): 300 mcg/kg (max 15 mg) 3-4 times daily
Side effects
Side Effects (>10%):
- Constipation
- Dry mouth
- Dry skin
- Decreased sweating
Side Effects (Frequency Not Defined):
- Blurred vision
- Sedation
- Tachycardia
- Dysphagia
- Urinary retention
- Potentially fatal: Toxic megacolon due to preexisting ulcerative colitis
Use in pregnancy
Use in Pregnancy: Pregnancy Category C; use only if clearly needed; animal reproduction studies not conducted.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in hyperthyroidism, congestive heart failure, coronary heart disease, cardiac arrhythmias, hypertension
- Caution in elderly, pregnancy, and lactation
- Caution in fever, diarrhea, GI reflux disease, or ulcerative colitis
- Caution in hepatic or renal impairment
- Caution in Down's syndrome
Overdose effects
Overdose: Progression from usual side effects to CNS disturbances (restlessness, psychotic behavior), circulatory changes, respiratory failure, paralysis.
Storage conditions
Do not store above 30°C; keep away from light; keep out of reach of children.