Prostig500mcg/ml
Rx- Generic:
- Neostigmine Methyl Sulphate
- Company:
- Chemist Laboratories Ltd.
- Dosage form:
- Injection
- Pack size:
- Injection
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৳ 8/unit
Pack: ৳ 8
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- ৳ 8
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- ৳ 6
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At a glance
Neostigmine Methyl Sulphate is a reversible cholinesterase inhibitor used for myasthenia gravis, paralytic ileus, post-operative urinary retention and reversal of skeletal muscle relaxant effects after surgery.
Indications
- Symptomatic control of myasthenia gravis (when oral therapy is impractical)
- Prevention and treatment of postoperative distention and urinary retention (after mechanical obstruction excluded)
- Reversal of effects of nondepolarizing neuromuscular blocking agents
Dosage
Reversal of Neuromuscular Blockade:
- Adults: 2-3 mg + atropine 0.6-1.2 mg, slow IV over 1 min; max 5 mg
- Children: 0.05 mg/kg + atropine 0.02 mg/kg, slow IV; max 2.5 mg
Myasthenia Gravis (Adults): 1-2.5 mg IM/SC, up to 5-20 mg daily
Myasthenia Gravis (Neonates): 0.05-0.25 mg IM every 2-4 hours
Urinary Retention Prophylaxis: 0.25 mg SC/IM every 4-6 hours for 2-3 days
Urinary Retention Treatment: 0.5 mg SC/IM
Side effects
Side Effects (Overdose):
- Cardiac arrhythmias (especially bradycardia)
- Hypotension, cardiac arrest, syncope
- Headache, dizziness, convulsions, coma
- Nausea, vomiting, diarrhea, abdominal cramps
- Muscle cramps, fasciculation, paralysis
- Respiratory depression, bronchospasm
- Allergic reactions (including anaphylaxis)
Precautions & warnings
- Caution in epilepsy, bronchial asthma, bradycardia, coronary occlusion, vagotonia, hyperthyroidism, cardiac arrhythmias or peptic ulcer
- Keep atropine and antishock medication readily available
- Overdose may cause cholinergic crisis (increasing muscle weakness)
- Important to differentiate from myasthenic crisis
- Caution while driving
- Avoid alcohol
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.