৳ 13/unit
Pack: ৳ 130
৳ 13/unit
Pack: ৳ 130
At a glance
Prucalopride is a selective 5-HT4 receptor agonist with prokinetic effect, used for symptomatic treatment of chronic constipation in adults in whom laxatives fail to provide adequate relief.
Indications
- Chronic constipation in adults (where laxatives fail to provide adequate relief)
Pharmacology
Prucalopride activates 5-HT4 receptors, causing acetylcholine release which is the major excitatory neurotransmitter in the GI tract. It stimulates contraction of the colon muscle layer and relaxation of the circular muscle layer, leading to propulsion of luminal content. It does not interact with hERG channels or 5-HT1 receptors, significantly reducing cardiovascular risk.
Dosage
Adult Dose (Oral):
- 2 mg once daily with or without food, at any time of the day
- Elderly: 1 mg once daily initially; may increase to 2 mg/day if needed
- Severe renal impairment (GFR <30 mL/min/1.73 m²): 1 mg once daily
- Severe hepatic impairment (Child-Pugh class C): 1 mg once daily initially; may increase to 2 mg/day if needed
Side effects
Common Side Effects:
- Headache (17.8%)
- Abdominal pain
- Nausea
- Diarrhea
Use in pregnancy
Use in Pregnancy: Information regarding use during pregnancy is not available; women of childbearing potential should use effective contraception.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability (dizziness, tiredness); especially on the first day
- Severe diarrhea may reduce efficacy of oral contraceptives; use additional contraceptive method
- Tablets contain lactose; patients with galactose intolerance should not take
- Inform doctor if no improvement after 4 weeks
Overdose effects
Overdose: Headache, nausea, diarrhea (exaggeration of effects); no specific treatment; symptomatic and supportive care; electrolyte correction for fluid loss from diarrhea/vomiting.
Storage conditions
Store at room temperature, below 30°C; do not remove desiccant; dispense in original bottle.