Pylopac

• H. pylori infection
• Peptic ulcer disease
• Duodenal ulcer

Clarithromycin inhibits protein synthesis by binding to 50s ribosomal subunits of susceptible organisms. Lansoprazole is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited. Metronidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.

Adult Dose: One strip containing lansoprazole 30 mg, clarithromycin 500 mg, and metronidazole 500 mg twice daily for 7-14 days.

Common Side Effects (<3% in clinical trials):

• Nausea
• Vomiting
• Diarrhea
• Dark stool
• Glossitis
• Oral moniliasis
• Stomatitis
• Tongue discoloration
• Myalgia
• Confusion
• Headache
• Dizziness
• Skin reactions
• Vaginitis
• Vaginal moniliasis

Safety during pregnancy has not been fully established. Use only if clearly needed and on the advice of a physician.

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy. Higher risk in individuals with history of penicillin hypersensitivity and/or sensitivity to multiple allergens.
• Contraindicated in patients with history of cholestatic jaundice/hepatic dysfunction associated with prior use of clarithromycin.
• Clarithromycin should not be given to patients with history of QT prolongation or ventricular cardiac arrhythmia, including torsades de pointes.

Overdose symptoms include severe gastrointestinal symptoms, CNS depression, and seizures. Seek immediate medical attention if overdose is suspected.

Store in a cool and dry place, protected from light & moisture. Keep out of reach of children.