৳ 18.05/unit
Pack: ৳ 180.50
৳ 18.05/unit
Pack: ৳ 180.50
At a glance
Quetiapine is an atypical antipsychotic used for schizophrenia, bipolar disorder (manic and depressive episodes), and major depressive disorder. It acts as an antagonist at multiple neurotransmitter receptors in the brain.
Indications
- Schizophrenia (acute and chronic psychoses)
- Bipolar disorder (manic episodes)
- Bipolar disorder (depressive episodes)
- Maintenance treatment of bipolar I disorder
- Major depressive disorder (adjunctive therapy)
Pharmacology
Quetiapine blocks serotonin 5HT2, dopamine D2, histamine H1, and adrenergic α1/α2 receptors in the brain. Efficacy in schizophrenia is mediated through a combination of dopamine D2 and serotonin 5HT2 antagonism. Histamine H1 antagonism may explain somnolence, and α1 antagonism may explain orthostatic hypotension.
Dosage
Adult Dose (Oral):
- Schizophrenia (IR): Day 1: 50 mg/day; Days 2-3: increase by 25-50 mg; Day 4: 300-400 mg; maintenance 150-750 mg/day
- Schizophrenia (XR): Day 1: 300 mg/day; Day 2+: increase by 300 mg/day; maintenance 400-800 mg/day
- Bipolar mania (IR): Day 1: 100 mg/day; Day 2: 200; Day 3: 300; Day 4: 400; Day 6: up to 800 mg/day; maintenance 400-800 mg/day
- Bipolar mania (XR): Day 1: 300 mg/day; Day 2: 600 mg/day; maintenance 400-800 mg/day
- Bipolar depression: Day 1: 50 mg at bedtime; Day 2: 100; Day 3: 200; Day 4: 300 mg at bedtime (maintenance)
- MDD (adjunct): Days 1-2: 50 mg in evening; Day 3: 150 mg in evening; maintenance 150-300 mg/day
- Elderly: Slower dose titration, lower therapeutic dose
- Hepatic impairment: 25 mg/day initially; increase by 25-50 mg
Side effects
Side Effects:
- Somnolence
- Dizziness
- Dry mouth
- Weight gain
- Increased serum triglycerides
- Increased total cholesterol (LDL)
- Decreased HDL cholesterol
- Decreased hemoglobin
- Extrapyramidal symptoms
- Akathisia
- Dystonia
- Parkinsonism
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Discontinue if Neuroleptic Malignant Syndrome (fever, muscle rigidity, altered consciousness) occurs
- Rise slowly to avoid orthostatic hypotension
- May cause weight gain, increased blood sugar and cholesterol; monitor regularly
- Do not stop abruptly
- Risk of suicidal thoughts or behavior; monitor
Overdose effects
Overdose (up to 30 g reported): Drowsiness, tachycardia, hypotension, QT prolongation; no specific antidote; airway maintenance, oxygenation, cardiovascular monitoring; refractory hypotension: IV fluids and sympathomimetics (avoid adrenaline and dopamine).
Storage conditions
Keep out of sight and reach of children; do not use after expiry date; store in a cool and dry place away from light.