৳ 1,000/unit
Pack: ৳ 1,000
৳ 1,000/unit
Pack: ৳ 1,000
At a glance
Rabies Immunoglobulin USP is used for seroprophylaxis of rabies in subjects suspected of exposure to rabies virus, particularly in severe exposures such as multiple transdermal bites or scratches, contamination of mucous membrane with saliva, severe bites on face, head, neck, and hands, and bites to young children.
Indications
- Seroprophylaxis of rabies in suspected exposure (especially severe exposure)
Pharmacology
Rabies Immunoglobulin provides immediate passive immunity against the rabies virus. It neutralizes the virus at the wound site and provides protection until vaccine-induced active immune response develops. Both active (vaccine) and passive (immunoglobulin) immunization prevent the rabies virus from infiltrating the CNS, but become ineffective once the virus has crossed into the CNS.
Dosage
Adult and Pediatric Dose (IM/Local):
- Recommended dose: 40 IU/kg body weight
- Infiltrate as much as possible around and into wound(s); remainder IM (gluteal region) in a single injection
- Administered only once in a lifetime
- Should be given within 7 days of the first rabies vaccine dose
- Administered simultaneously with the first dose of rabies vaccine (at different sites)
Side effects
Side Effects:
- Immediate: Hypotension, dyspnea, urticaria
- Delayed: Inflammatory reaction, fever, pruritus, rash, adenopathy, arthralgia
Use in pregnancy
Use in Pregnancy: Safety not established during pregnancy; however, due to lethal risk of rabies, pregnancy is not a contraindication.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- History of allergic symptoms to horse proteins; however, lethal risk of rabies overcomes any contraindication
- Do not administer in repeated doses (may reduce vaccine protective efficacy)
- Pregnancy is not a contraindication to rabies immunoglobulin administration (due to lethal risk of rabies)
Overdose effects
Overdose: If recommended dosage is not strictly observed, risk of immunosuppressive interference (suppression of vaccine protective efficacy).
Storage conditions
Store at 2-8°C; transport also at 2-8°C; protect from light; do not freeze; keep out of reach and sight of children.