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Ragil 0.5

Rx
Generic: Rasagiline

৳ 15/unit

Pack: ৳ 150

TabletStrip (10 Tablet)
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At a glance

Rasagiline is an irreversible, selective MAO-B inhibitor used as monotherapy or adjunct therapy for Parkinson's disease. It increases extracellular dopamine levels in the striatum, reducing motor deficits.

Indications
  • Parkinson's disease (monotherapy)
  • Parkinson's disease (adjunct therapy with levodopa)
Pharmacology

Rasagiline is an irreversible MAO-B inhibitor that increases extracellular dopamine levels in the striatum. It reduces dopamine breakdown and enhances dopaminergic tone, improving motor symptoms in Parkinson's disease.

Dosage

Adult Dose (Oral):

  • Monotherapy (without levodopa): 1 mg once daily
  • Adjunct with levodopa: 0.5 mg once daily initially; may increase to 1 mg/day if needed and tolerated; consider reducing levodopa dose
  • Mild hepatic impairment: Not to exceed 0.5 mg/day
  • Moderate-severe hepatic impairment: Do not use
Side effects

Common Side Effects:

  • Joint pain
  • Insomnia
  • Dyspepsia
  • Flu-like symptoms
  • Depression
  • Cough
  • Peripheral edema
  • Headache
  • Dizziness
  • Dry mouth
  • Loss of appetite
  • Constipation/diarrhea
  • Weight loss
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability; do not drive if drowsy or dizzy
  • Do not stop suddenly (may cause confusion, stiff muscles, high fever)
  • Avoid foods high in tyramine (aged cheeses, air-dried meat, soy sauce, tap/draft beers, red wine) due to risk of hypertensive reaction
  • Serotonin syndrome: Caution with SSRIs, SNRIs, TCAs
Overdose effects

Overdose: Drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, seizures, coma, hypertension/hypotension, respiratory depression, hyperpyrexia; no specific antidote; supportive care, tyramine-restricted diet for several weeks.

Storage conditions

Store at temperature not exceeding 30°C in a dry place; protect from light; keep out of reach of children.

Rasagiline — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.