osudhkosh
New
Company•General Pharmaceuticals Ltd.

Ranola ER 500

Rx
Generic: Ranolazine

৳ 16.05/unit

Pack: ৳ 192.60

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At a glance

Ranolazine is an anti-anginal medication used for the treatment of chronic angina. It helps prevent new attacks of angina by decreasing the oxygen requirement of the heart through relaxation of heart muscle, but does not stop an acute attack once it has started.

Indications
  • Chronic angina
Pharmacology

Ranolazine inhibits the late Na current, reducing intracellular Na concentrations and reversing Ca overload, which restores ventricular pump function and prevents ischaemia-induced arrhythmias. Its antianginal effects are not dependent on heart rate or blood pressure reduction. QT prolongation is caused by IKr inhibition.

Dosage

Adult Dose (Oral):

  • Initial dose: 500 mg twice daily
  • May increase to 1000 mg twice daily if needed
  • Maximum daily dose: 1000 mg twice daily
  • With moderate CYP3A4 inhibitors: Max 500 mg twice daily
  • Mild hepatic impairment: Dose titration needed; Moderate-severe: Contraindicated
  • Renal impairment (CrCl 30-80 mL/min): Dose titration needed; CrCl <30 mL/min: Contraindicated
Side effects

Side Effects:

  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Constipation
  • Weakness
  • Bradycardia
  • Palpitations
  • Tinnitus
  • Vertigo
  • Abdominal pain
  • Dry mouth
  • Peripheral edema
  • Dyspnea
  • Hypotension
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability; do not drive if dizzy or drowsy
  • Take with food to avoid stomach upset
  • ECG should be performed (QTc interval may be prolonged)
  • May improve HbA1c and blood sugar in diabetics
  • Avoid alcohol
Overdose effects

Overdose: Dizziness, nausea, vomiting (dose-related); high IV doses: diplopia, paresthesia, confusion, syncope; treatment: supportive measures, continuous ECG monitoring; hemodialysis is unlikely to be effective (62% protein-bound).

Storage conditions

Store below 30°C, away from light and moisture; keep out of reach of children.

Ranolazine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.