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At a glance

Mirtazapine is an antidepressant used for the treatment of major depressive disorder.

Indications
  • Major Depressive Disorder (MDD)
  • Depression
Pharmacology

Mirtazapine acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors increasing noradrenergic and serotonergic activity.

Dosage

Adult Dose (Oral):

  • Initial Dose: 15 mg/day (at bedtime)
  • Maintenance: 15-45 mg/day (single dose or 2 divided doses)
  • Elderly: 7.5 mg/day (at bedtime); gradual increase; Max 45 mg/day

Child Dose: Safety and efficacy not established.

Side effects

Common Side Effects:

  • Drowsiness and somnolence
  • Dry mouth
  • Increased appetite and weight gain
  • Headache
  • Dizziness
Use in pregnancy

Use in Pregnancy (Category C): Possibly unsafe. Animal studies show harmful effects.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution while driving (may cause drowsiness and dizziness)
  • Do not stop abruptly (taper dose over 4 weeks)
  • Avoid alcohol
  • Inform doctor if sore throat or fever occurs
Overdose effects

Overdose may cause excessive sedation confusion drowsiness tachycardia.

Storage conditions

Store below 30°C away from light and moisture. Keep out of reach of children.

Mirtazapine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.