Rhophylac 300

• Pregnancy and Other Obstetrical Conditions in Rh-Negative Women: unless the father or baby are conclusively Rh negative
• Pregnancy/delivery of an Rh-positive baby
• Abortion/threatened abortion - at any stage of gestation
• Ectopic pregnancy
• Antepartum fetal-maternal hemorrhage
• Transfusion of Rh incompatible blood or blood products

Anti-D immunoglobulin prevents a rhesus-negative mother from actively forming antibodies to foetal rhesus-positive RBCs that may pass into the maternal circulation during childbirth, abortion, or certain other sensitising events. It is also used in idiopathic thrombocytopenic purpura to prevent excessive bleeding.

Adult Dose (IM):

• After delivery/abortion: 250 mcg immediately or as soon as possible (within 48 hours, not >72 hours)

Antenatal Prophylaxis:

• 250 mcg at week 28 & week 34 of pregnancy

Sensitising episode (up to 20 weeks):

• 125 mcg per episode

Sensitising episode (after 20 weeks):

• 250 mcg immediately or within 72 hours

* Use as directed by the registered physician

Common Side Effects:

• Nausea
• Dizziness
• Headache
• Injection-site pain and tenderness
• Malaise
• Fever, chills
• Flushing
• Hypersensitivity reactions (hives, wheezing, urticaria)

Serious (in ITP treatment): Intravascular hemolysis, anemia, acute renal insufficiency, DIC, death

Use in Pregnancy: Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus.

Precautions:

• For maternal administration only (postpartum use)
• Not for rhesus-positive individuals
• IgA deficient patients with antibodies to IgA are at greater risk of severe hypersensitivity and anaphylactic reactions
• Made from human blood - may contain infectious agents

Overdose: Limited information available on overdose. Employ usual supportive measures.

Storage: Store in a cool and dry place.