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Isoniazid + Rifampicin is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection. Isoniazid + Rifampicin is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve. Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help. Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body. Isoniazid + Rifampicin is a combination of two antibiotics: Rifampicin and Isoniazid, which treats tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

• Tuberculosis (TB)

Rifampicin and isoniazid are active bactericidal anti-TB drugs which are particularly active against the rapidly growing extracellular organisms and also have bactericidal activity intracellularly. Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts w/ bacterial RNA polymerase but does not inhibit the mammalian enzyme. Cross-resistance to rifampicin has only been shown w/ other rifamycins. It has activity against slow- and intermittently-growing M. tuberculosis. Isoniazid acts against actively growing tubercle bacilli.

Adult Dose: Oral Tuberculosis Adult: Each tab contains rifampicin and isoniazid (mg): 50 kg: 2 tab of 300/150 once daily. Hepatic impairment: Max: 8 mg/kg daily.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isoniazid + Rifampicin is to be taken empty stomach. Avoid Isoniazid + Rifampicin with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

Common: • Dark colored urine • Rash • Vomiting • Jaundice • Fever • Increased liver enzymes • Nausea • Peripheral neuropathy (tingling and numbness of feet and hand)

[UNSAFE] Isoniazid + Rifampicin may cause side effects which could affect your ability to drive. Isoniazid + Rifampicin can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability. You have been prescribed Isoniazid + Rifampicin for the treatment of tuberculosis. Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back. Take it on an empty stomach, preferably at the same time everyday. It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Avoid drinking alcohol while taking Isoniazid + Rifampicin as this may increase the risk of side effects on the liver. Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Isoniazid + Rifampicin as it may make hormonal contraceptives such as the pill less effective. Do not take indigestion remedies (antacids) within at least two hours of taking Isoniazid + Rifampicin.

Known or suspected hypersensitivity to rifamycins and/or to INH, and/or to any of the excipients including a history of drug-induced hepatitis; acute liver diseases, regardless of their origin; peripheral neuritis.

May reduce effectivity of hormonal contraceptives. Reduced absorption w/ antacids. May decrease plasma concentrations of antivirals (e.g. atazanavir, darunavir, fosamprenavir), atovaquone w/ rifampicin. Rifampicin may reduce serum levels of anticonvulsants (e.g. phenytoin), antiarrhythmics (e.g. disopyramide), oral anticoagulants, antifungals (e.g. ketoconazole), barbiturates, ?-blockers, Ca channel blockers (e.g. diltiazem), chloramphenicol, clarithromycin, corticosteroids, ciclosporin, cardiac glycosides, clofibrate, dapsone, diazepam, doxycycline, fluoroquinolones (e.g. ciprofloxacin), haloperidol, oral hypoglycemic agents (sulfonylureas), levothyroxine, methadone, narcotic analgesics, progestins, quinine, tacrolimus, theophylline, TCAs (e.g. amitriptyline, nortriptyline) and zidovudine. Increased risk of hepatotoxicity w/ halothane. Isoniazid may inhibit the metabolism of anticonvulsants (e.g. carbamazepine, phenytoin), benzodiazepines (e.g. diazepam), haloperidol, ketoconazole, theophylline, and warfarin. May enhance the CNS effects of meperidine, cycloserine, and disulfiram w/ isoniazid. Loss of glucose control in patients on oral hypoglycaemics w/ isoniazid. Potentially Fatal: Concurrent treatment w/ saquinavir/ritonavir combination may result to severe hepatoxicity.

[UNSAFE] Consuming alcohol while taking Isoniazid + Rifampicin may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

[CONSULT YOUR DOCTOR] Isoniazid + Rifampicin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Isoniazid + Rifampicin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CAUTION] Isoniazid + Rifampicin should be used with caution in patients with kidney disease. Dose adjustment of Isoniazid + Rifampicin may be needed. Please consult your doctor. [CAUTION] Isoniazid + Rifampicin should be used with caution in patients with liver disease. Dose adjustment of Isoniazid + Rifampicin may be needed. Please consult your doctor. Use of Isoniazid + Rifampicin is not recommended in patients with severe liver disease.

Born TB medicine for week patient whoes taking less food.blood 9gram.urin drain more then taking water .alsar in stomk.samisolid dait . Both legs not working Tab AKT-4 kit once daily For complete prescription detailed evaluation of the patient's condition is required Dear sir, I am kumar Gautam & my wife name is PATIENT suffering of infertility problem during 4 years. Tb pcr detected during laparoscopy & hysterocopy operation. suggest Akt 4 tablet for 2 months than Akt3 tablets for 4 months.just 3 months completed today. My wife is suffering dry caugh from 2 months. Is dry cough side effects from Akt 4 and Akt 3 tablets. Sir/Madam Give me the best solutions Regard Kumar Gautam Berhampore no usually att does not lead to cough but still she has stopped it so see for a few days whether it stops. Also i dont know about the cause of your infertility problem but you can go through my website www.drsonubalhara.in Can I take weight reduction course with akt 4 treatment? It include garcinia Cambogia plant extract capsule, apple cider vinegar and slim shake. no u should not take anything , first complete ur AKT full course Was detected with TB infectn in my supraclavicular lymph node in January post surgical removal of the node started on AKT4 for 60 days, after that switched to AKT 2 since 23rd march(completing 6 months on 23rd Aug). Current ESR count is Please advise if meds can be stopped no complete the medicine courseand also u need to refer ur self to dots centre or TB 7 CHest specialist I have gland tb since last 2 months and taking akt drug from 06.03.2017. But yesterday it opens though a small channel and yellowish fluid is coming out from the infected area. Why it is happening and what should I do? it can happen as before starting treatment also u might be having some pus visit ent specialist near you for proper examination and cleaning of pus continue your medicines Sir I'm a tb patient and I have been said to take Akt-4 and few other medines for a period of time,but unfortunately I missed my two doses of AKT-4 so I want to ask that will I have to restart my doses from the beginning. If only two doses are missed continue as before no need to re start My daughter is given tb medicine even though she is not infected taking these medicine will cause tb??? Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis. I have oncular tuberculosis (NOW CURED) in my eyes since may 2015 taken AKT KIT FOR 6 MONTHS at present my vision is 10% in right eye and 50% in left it could be due to scarringonce scar develop at your central retina almost impossible to cureif he cud help