৳ 300/unit
Pack: ৳ 300
৳ 300/unit
Pack: ৳ 300
At a glance
Rocuronium Bromide is a non-depolarizing muscle relaxant used during general anesthesia to facilitate tracheal intubation and provide skeletal muscle relaxation during surgery. It is also used in the ICU to facilitate intubation and mechanical ventilation.
Indications
- To facilitate tracheal intubation during routine anesthesia
- To provide skeletal muscle relaxation during surgery
- As an adjunct in the ICU to facilitate intubation and mechanical ventilation
Pharmacology
Rocuronium competes with acetylcholine for nicotinic receptors at the motor end-plate, preventing depolarization and muscle contraction. It inhibits calcium ion release and is antagonized by acetylcholinesterase inhibitors like neostigmine.
Dosage
Adult Dose (IV):
- Routine intubation: 0.6 mg/kg (intubation within 60 seconds)
- Rapid sequence intubation: 1.0 mg/kg (intubation within 60 seconds) or 0.6 mg/kg (at 90 seconds)
- Maintenance: 0.15 mg/kg (0.075-0.1 mg/kg with inhalational anesthesia)
- Continuous infusion: Loading 0.6 mg/kg; then 0.3-0.6 mg/kg/hr (IV anesthesia) or 0.3-0.4 mg/kg/hr (inhalational)
Pediatric (1-14 years):
- Similar sensitivity to adults under halothane; faster onset and shorter duration in children
Elderly & Hepatic/Renal Failure:
- Intubation: 0.6 mg/kg; Maintenance: 0.075-0.1 mg/kg; Infusion: 0.3-0.4 mg/kg/hr
Side effects
Common Side Effects (≥2%):
- Transient hypotension and hypertension
- Pain on injection (16% with propofol in rapid sequence induction)
Other:
- Anaphylactic/anaphylactoid reactions (rare but fatal)
- Prolonged neuromuscular block
- Myopathy (with corticosteroids in ICU)
Use in pregnancy
Use in Pregnancy: No harmful effects in animal studies; use with caution; 0.6 mg/kg is safe for Caesarean section; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Anaphylactic reactions possible; take necessary precautions
- Histamine release may occur (itching, erythema)
- Prolonged block requires ventilatory support
- Caution in severe hepatic/biliary tract disease and renal failure
Overdose effects
Overdose and prolonged block: Continue ventilatory support and sedation; reverse with sugammadex (intense/deep block) or acetylcholinesterase inhibitors (neostigmine) at reappearance of T2.
Storage conditions
Store in a refrigerator at 2-8°C; do not freeze; keep out of reach of children.