Rolip 10 Sprinkle10mg

• Primary Hyperlipidemia: As an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, non-HDL-C and TG, and increase HDL-C. • Mixed Dyslipidemia: As an adjunct to diet to reduce elevated total-C, LDL-C and ApoB. • Hypertriglyceridemia: As an adjunct to diet to reduce triglycerides. • Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia): As an adjunct to diet to reduce lipids. • Homozygous Familial Hypercholesterolemia (HoFH): To reduce LDL-C, total-C and ApoB. • Heterozygous Familial Hypercholesterolemia (HeFH) – Children (10–17 years): To reduce elevated total-C, LDL-C and ApoB after failing diet therapy. • Slowing Atherosclerosis Progression: As an adjunct to diet to lower total-C and LDL-C. • Prevention of MI, Stroke & Arterial Revascularization: In patients without CHD but with multiple risk factors.

• Primary Hyperlipidemia: Initial dose 5–10 mg once daily; maximum dose 40 mg once daily. Dose can be increased every 4 weeks. • Mixed Dyslipidemia: Initial dose 5–10 mg once daily; maximum dose 40 mg once daily. Dose should be determined according to the doctor's advice. • Hypertriglyceridemia: Initial dose 5–10 mg once daily; maximum dose 40 mg once daily. Regular lipid profile monitoring is recommended. • Dysbetalipoproteinemia: Initial dose 5–10 mg once daily; maximum dose 40 mg once daily. Use with diet control. • Homozygous Familial Hypercholesterolemia (HoFH): Initial dose 20 mg once daily; maximum dose 40 mg once daily. Preapheresis LDL-C should be assessed. • Very High Cholesterol & High Risk (MI/Stroke): Dose 40 mg once daily; maximum dose 40 mg once daily. For high-risk patients. • Asian Patients: Initial dose 5 mg once daily; maximum dose 20 mg once daily. Start with a lower dose.

Common Side Effects (in 5–10% patients): • Headache • Myalgia (Muscle pain) • Constipation • Asthenia (Weakness) • Abdominal pain • Nausea • Diarrhea • Gas or upset stomach Serious Side Effects (Rare – Consult Doctor): • Yellowing of eyes or skin (jaundice) – sign of liver problems • Dark urine – sign of liver problems • Severe stomach pain – sign of liver problems • Repeated or unexplained muscle pain – sign of myopathy • Muscle weakness or fatigue – sign of myopathy • Rhabdomyolysis (muscle breakdown) – rare but serious • Elevated liver enzymes (SGOT/SGPT) • Memory loss (rare) • Increased blood sugar (in diabetic patients)

• Does not usually affect driving ability. • Follow regular exercise and a low-fat diet (e.g., green leafy vegetables, fruits, whole grains). • Diabetic patients should monitor blood sugar regularly, as this medicine may increase blood sugar. • Perform liver function tests (SGOT, SGPT) before starting treatment, at 12 weeks, and regularly thereafter (e.g., every 6 months). • Inform your doctor if you have kidney disease, liver disease, thyroid problems, or diabetes. • Contraindicated during pregnancy and breastfeeding. • A lower starting dose of 5 mg is recommended for Asian patients. • Patients over 65 years have a higher risk of muscle problems; caution is required. • Perform liver function tests 12 weeks after any dose increase. • Discontinue the medicine if creatine kinase (CK) levels rise significantly or if myopathy is suspected. • Temporarily withhold the medicine in cases of sepsis, hypotension, dehydration, major surgery, trauma, severe metabolic/endocrine/electrolyte disorders, or uncontrolled seizures.