৳ 4/unit
Pack: ৳ 40
৳ 4/unit
Pack: ৳ 40
At a glance
Ropinirole is a non-ergot dopamine agonist used for Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome (RLS). It stimulates dopamine receptors in the brain to improve motor control and reduce leg discomfort.
Indications
- Idiopathic Parkinson's disease (monotherapy or with levodopa)
- Moderate-to-severe primary Restless Legs Syndrome (RLS)
Pharmacology
Ropinirole stimulates dopamine D2 receptors (particularly D3) in the striatum, improving motor control in Parkinson's by compensating for dopamine deficiency. In RLS, it reduces leg discomfort and urge to move by stimulating dopamine receptors, though the exact mechanism is unknown.
Dosage
Adult Dose (Oral):
Parkinson's Disease:
- Initial: 0.25 mg three times daily
- Weekly titration: Week 1: 0.25 mg x3; Week 2: 0.5 mg x3; Week 3: 0.75 mg x3; Week 4: 1 mg x3; then increase by 1.5 mg/week up to 9 mg/day; then 3 mg/week up to 24 mg/day
- Maintenance: 3-9 mg/day (max 24 mg/day)
Restless Legs Syndrome (RLS):
- Initial: 0.25 mg/day (1-3 hours before bedtime) for 2 days
- Titration: 0.5 mg/day (next 2 days); then 0.5 mg/week up to 3 mg/day; max 4 mg/day
Side effects
Common Side Effects:
- Headache, dizziness, and somnolence
- Nausea and vomiting
- Syncope and orthostatic hypotension
- Hallucinations and confusion
- Abnormal involuntary movements (dyskinesia)
- Leg edema and weakness
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause sudden sleep onset during daily activities; avoid driving
- Orthostatic hypotension: change positions slowly
- Report compulsive behaviors (gambling, excessive spending, hypersexuality) – impulse control disorders
- Do not stop abruptly (withdrawal syndrome)
- Caution in pregnancy and lactation
Overdose effects
Overdose may increase dopamine agonist side effects; consult your doctor; no specific antidote.
Storage conditions
Store below 25°C, protected from light and moisture; keep out of reach of children.