Rosutin EZ 5/105mg+10mg
Rx- Generic:
- Rosuvastatin+ Ezetimibe
- Company:
- Beximco Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
৳ 13/unit
Pack: ৳ 130
Price comparison
- This brand
- ৳ 13
- Cheapest of this genericCreston EZ 5/10
- ৳ 12
The cheaper brand costs ৳ 1.00 less per unit
Compared against 7 brands
At a glance
Rosuvastatin + Ezetimibe is a dual-action lipid-lowering medicine. Rosuvastatin reduces cholesterol production in the liver, while Ezetimibe prevents cholesterol absorption from the intestine. This combination is used to lower LDL cholesterol in patients with primary non-familial hyperlipidemia and homozygous familial hypercholesterolemia (HoFH). It should be taken with diet control. In Bangladesh, it is available under brand names like Rosuvas EZ, Crestor EZ, etc.
Indications
• Primary Non-familial Hyperlipidemia: As an adjunct to diet to reduce LDL-C. • Homozygous Familial Hypercholesterolemia (HoFH): Alone or as an adjunct to other LDL-C-lowering therapies to reduce LDL-C.
Dosage
• General Patients: 5/10 mg to 40/10 mg once daily; maximum dose is 40/10 mg once daily. Dose depends on the indication, LDL-C level, and cardiovascular risk. • Severe Renal Impairment (CrCl <30 mL/min) – Not on Hemodialysis: 5/10 mg once daily; maximum dose is 10/10 mg once daily. • Elderly Patients: No dosage adjustment is necessary. • Pediatric Patients: Safety and efficacy have not been established.
Side effects
• Headache • Nausea • Myalgia (Muscle pain) • Arthralgia (Joint pain) • Dizziness • Asthenia (Weakness) • Constipation • Abdominal pain • Respiratory tract infection • Diarrhea • Sinusitis • Pain in extremity • Fatigue • Influenza • Back pain Serious Side Effects (Rare – Consult Doctor): • Myopathy and Rhabdomyolysis (muscle breakdown) • Elevated liver enzymes • Hepatic failure (rare)
Precautions & warnings
Myopathy and Rhabdomyolysis: • Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher dosage. • Discontinue the medicine if markedly elevated creatine kinase (CK) levels occur or if myopathy is diagnosed or suspected. • Temporarily discontinue the medicine in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis. Hepatic Dysfunction: • Increases in serum transaminases may occur, and some cases may be persistent. • Rare reports of fatal and non-fatal hepatic failure have been reported. • Consider liver enzyme testing before initiating therapy and as clinically indicated thereafter.