৳ 15/unit
Pack: ৳ 150
৳ 15/unit
Pack: ৳ 150
At a glance
Propafenone Hydrochloride is a class 1C antiarrhythmic drug used for the treatment of paroxysmal atrial fibrillation/flutter, paroxysmal supraventricular tachycardia, and documented ventricular arrhythmias.
Indications
- Paroxysmal atrial fibrillation/flutter (PAF)
- Paroxysmal supraventricular tachycardia (PSVT)
- Documented ventricular arrhythmias
Pharmacology
Propafenone slows sodium ion influx into cardiac muscle cells, decreasing cell excitability. It is more selective for cells with a high rate, but also blocks normal cells more than class Ia or Ib. It has additional beta-adrenergic blocking activity which can cause bradycardia and bronchospasm.
Dosage
Adult Dose (Oral):
- Initial dose: 150 mg three times daily (450 mg/day)
- May increase at 3-4 day intervals to 225 mg three times daily (675 mg/day); if needed, to 300 mg three times daily (900 mg/day)
- Max dose: 900 mg/day
- Patients <70 kg: Dose reduction recommended
- Elderly and hepatic impairment: Dose reduction recommended
Side effects
Side Effects:
- Change in taste
- Constipation
- Diarrhea
- Dizziness
- Drowsiness
- Dry mouth
- Headache
- Nausea
- Tiredness
- Abdominal pain
- Blurred vision
- Palpitations
- Shortness of breath
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; use only if benefit outweighs risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if tired, dizzy, or have blurred vision
- Do not stop abruptly
- Monitor liver function
- Monitor potassium and sodium levels
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Store at 25°C; store in a cool and dry place, protected from light; keep out of reach of children.