৳ 4,500/unit
Pack: ৳ 4,500
৳ 4,500/unit
Pack: ৳ 4,500
At a glance
Streptokinase is a thrombolytic used for acute transmural myocardial infarction, deep vein thrombosis, pulmonary embolism, and peripheral arterial thrombosis. It dissolves blood clots by converting plasminogen to plasmin.
Indications
- Acute transmural myocardial infarction (within 12 hours)
- Deep vein thrombosis (DVT – within 14 days)
- Acute massive pulmonary embolism (PE)
- Acute and subacute peripheral arterial thrombosis
- Central retinal artery or vein occlusion
Pharmacology
Streptokinase forms a complex with plasminogen that converts plasminogen to plasmin. Plasmin degrades fibrin clots, fibrinogen, and other plasma proteins. This dissolves blood clots, restores blood flow, and prevents tissue death.
Dosage
Adult Dose (IV):
- Acute MI: 1.5 million units as a single dose over 60 minutes
- PE/Peripheral occlusion: Loading 250,000 units over 30 min; Maintenance 100,000 units/hr for 24-72 hours
Pediatric Dose (IV):
- Loading: 2500-4000 units/kg over 30 min; Infusion: 500-1000 units/kg/hr
Side effects
Serious Side Effects:
- Bleeding (major – 0.2-0.3%; minor – up to 10%)
- Allergic reactions (anaphylactic shock – 0.1%; mild allergy – 2-20%)
- Hypotension, arrhythmias
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in bleeding disorders, active internal bleeding, recent trauma/surgery, severe uncontrolled hypertension
- Do not use in recent stroke, intracranial neoplasm, subacute bacterial endocarditis
- Caution in pregnancy, age >75 years
Overdose effects
Overdose is unlikely (hospital use); overdose may lead to hemorrhage; antifibrinolytic therapy, blood transfusions, cryoprecipitate or fresh frozen plasma may be needed.
Storage conditions
Store at 2-8°C; reconstituted solution stable for 24 hours at 2-8°C; contains no preservative, use immediately; keep out of reach of children.