Sefacin125mg/1.25ml
Rx- Generic:
- Cephradine
- Company:
- Kumudini Pharma Ltd.
- Dosage form:
- Pediatric Drops
- Pack size:
- 15ml bot
৳ 60/unit
Pack: ৳ 60
Price comparison
- This brand
- ৳ 60
- Cheapest of this genericCephradine
- ৳ 1
The cheaper brand costs ৳ 59.00 less per unit
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At a glance
Cephradine is a first generation cephalosporin antibiotic used to treat pneumonia, pharyngitis, otitis media, skin infections, respiratory tract and urinary tract infections.
Indications
- Upper Respiratory Tract Infections (sinusitis, pharyngitis, tonsillitis, otitis media)
- Lower Respiratory Tract Infections (bronchitis, lobar pneumonia)
- Urinary Tract Infections (cystitis, urethritis, pyelonephritis)
- Skin and Soft Tissue Infections (abscess, cellulitis, furunculosis, impetigo)
- Surgical Prophylaxis
- Genitourinary Tract Infections
- Acute Prostatitis
Dosage
Adult Dose (Oral):
| Infection Type | Dose | Schedule |
|---|---|---|
| Susceptible infections | 1-2 g/day | 2-4 divided doses (Max 4 g/day) |
| Skin, Respiratory tract infections | 250 mg or 500 mg | Every 6 hours or every 12 hours |
| Lobar pneumonia | 500 mg or 1 g | Every 6 hours or every 12 hours |
| Urinary tract infections | 500 mg | Every 12 hours |
| GI tract infections | 500 mg | 3-4 times daily |
Adult Dose (Parenteral): Severe infections 2-4 g/day (4 divided doses), Max 8 g/day.
Surgical Prophylaxis: 1-2 g pre-op (IM/IV).
Pediatric Dose (Oral): 25-50 mg/kg/day (2-4 divided doses); Otitis media: 75-100 mg/kg/day (6-12 hourly).
Pediatric Dose (Injection): 50-100 mg/kg/day (4 divided doses); severe infections up to 200-300 mg/kg/day.
Renal Dose:
| Creatinine Clearance (ml/min) | Dose | Schedule |
|---|---|---|
| >20 | 500 mg | Every 6 hours |
| 5-20 | 250 mg | Every 6 hours |
| <5 | 250 mg | Every 12 hours |
Side effects
Common Side Effects:
- Diarrhea
- Nausea
- Vomiting
- Leukopenia
- Neutropenia
- Eosinophilia
- Rash
- Pruritus
- Joint pain
- Increased BUN and creatinine
- Dizziness
Rare: Glossitis, heartburn, chest tightness, abdominal pain, vaginitis, candida overgrowth, blood disorders, hepatic enzyme elevation, interstitial nephritis.
Potentially Fatal: Pseudomembranous colitis.
Precautions & warnings
- Use with caution in renal impairment; dose adjustment needed.
- History of penicillin sensitivity; caution due to cross-sensitivity risk.
- Prolonged use may result in superinfection due to resistant organisms.
- Caution during pregnancy and lactation.
- Cephalosporins may cause false positive Coombs' test.
- May cause false positive urine glucose with Benedict's or Fehling's solutions or Clinitest tablets.
- Contains lactose; not recommended for patients with galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.