Setorib 120

• Osteoarthritis: Used for symptomatic relief.
• Rheumatoid Arthritis: Used for symptomatic relief.
• Ankylosing Spondylitis: Used for symptomatic relief.
• Acute Gouty Arthritis: Used for pain and inflammation.
• Post-Dental Surgery Pain: Used for short-term treatment.

Etoricoxib is a potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. Selective inhibition of COX-2 by etoricoxib decreases these clinical signs and symptoms. Etoricoxib produced dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150 mg daily.

Adult Dose (Oral):

• Osteoarthritis: 30 mg once daily; may increase to 60 mg if needed.
• Rheumatoid Arthritis, Ankylosing Spondylitis: 90 mg once daily.
• Acute Gout: 120 mg once daily; max 8 days.
• Post-Dental Surgery Pain: 90 mg once daily; max 3 days.
• Mild Hepatic Impairment (Child-Pugh 5-6): 60 mg once daily.
• Moderate Hepatic Impairment (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily.

Child Dose (<16 years): Contraindicated.

Common Side Effects:

• Stomach pain
• Diarrhea
• Edema
• Dizziness
• Headache
• Irregular heartbeat
• Increased blood pressure
• Fatigue
• Influenza-like symptoms

Less Common: Dry mouth, taste disturbance, mouth ulcer, atrial fibrillation, transient ischaemic attack, chest pain, flushing, cough, dyspnoea, epistaxis, anxiety, paraesthesia, electrolyte disturbance.

Use in Pregnancy: Etoricoxib may be unsafe; animal studies have shown harmful effects on the developing baby.

Precautions:

• Etoricoxib may decrease alertness, affect vision or make you feel sleepy and dizzy; do not drive if these symptoms occur.
• Helps relieve pain and inflammation; may cause fewer stomach problems compared to other NSAIDs.
• May cause dizziness and fatigue; do not drive or do anything requiring concentration until you know how it affects you.
• Avoid alcohol (may cause excessive drowsiness).
• Regularly monitor blood pressure, particularly in the first two weeks.
• Inform doctor if you have history of stomach ulcers, heart diseases, high blood pressure, liver or kidney disease.
• During long-term treatment, doctor may monitor liver function.

Overdose: Single doses up to 500 mg and multiple doses up to 150 mg/day for 21 days did not result in significant toxicity. In case of overdose, employ usual supportive measures.

Storage: Store below 30 degree C, protect from light and moisture. Keep out of reach of children.