৳ 8.05/unit
Pack: ৳ 112.70
৳ 8.05/unit
Pack: ৳ 112.70
At a glance
Sitagliptin is a DPP-4 inhibitor used for the treatment of type 2 diabetes mellitus. It slows the inactivation of incretin hormones, increasing insulin release and decreasing glucagon levels.
Indications
- Type 2 diabetes mellitus (as an adjunct to diet and exercise)
Pharmacology
Sitagliptin inhibits DPP-4 enzyme, slowing the breakdown of incretin hormones (GLP-1 and GIP). Increased active incretin levels enhance insulin release from pancreatic beta cells and reduce glucagon secretion from alpha cells, decreasing hepatic glucose production and improving glycemic control.
Dosage
Adult Dose (Oral):
- Recommended: 100 mg once daily
- Renal Impairment:
- CrCl >50: 100 mg/day
- CrCl 30-50: 50 mg/day
- CrCl <30 or ESRD: 25 mg/day
Side effects
Common Side Effects:
- Headache
- Upper respiratory tract infection
- Nasopharyngitis
- Hypoglycemia (with sulfonylurea or insulin)
Use in pregnancy
Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; consult your doctor.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Not effective in type 1 diabetes or diabetic ketoacidosis
- Caution in history of pancreatitis; discontinue if suspected
- Be aware of hypoglycemia symptoms
- Dose adjustment needed in severe renal impairment
Overdose effects
Overdose up to 800 mg was tolerated; slight QTc increase (not clinically important); 13.5% removed by hemodialysis; provide symptomatic treatment.
Storage conditions
Store below 25°C in a dry place, protected from light; keep out of reach of children.