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At a glance

Sodium Bicarbonate is an antacid and alkalizer used for heartburn, indigestion, gas, and metabolic acidosis. It neutralizes stomach acid and increases blood and urine pH.

Indications
  • Acidosis management in cardiac arrest
  • Urine alkalinization
  • Metabolic acidosis (severe renal disease, uncontrolled diabetes, circulatory insufficiency from shock/dehydration, severe primary lactic acidosis)
  • Indigestion, heartburn, gas
Pharmacology

Sodium Bicarbonate increases plasma bicarbonate, buffers excess hydrogen ions, and raises blood pH to reverse acidosis. As a urinary alkalizer, it increases free bicarbonate ion excretion in urine to raise urinary pH. It replenishes electrolyte balance in severe diarrhea with significant bicarbonate loss.

Dosage

Adult Dose (Oral):

  • 300 mg to 2 g, 1-4 times daily

Intravenous (Severe metabolic acidosis):

  • Adults: Slow injection of 8.4% hypertonic solution or continuous infusion of 1.26% solution; 50 ml of 8.4% solution in cardiac life support
Side effects

Common Side Effects:

  • Stomach cramps
  • Flatulence
  • Headache, nausea, irritability

Serious (Inform doctor):

  • Muscle weakness, slow reflexes, confusion
  • Swelling of feet or ankles
  • Black tar-like stools, coffee-ground vomit
Use in pregnancy

Use in Pregnancy: May be unsafe; animal studies show adverse renal effects; not recommended in second and third trimesters; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution in pre-existing heart, kidney, liver disease, hypertension
  • Caution on salt-restricted diets (sodium content)
  • Avoid use in second and third trimesters of pregnancy
Overdose effects

If alkalosis occurs, stop bicarbonate; administer 0.9% sodium chloride IV; potassium chloride if hypokalemic; severe alkalosis may require calcium gluconate or ammonium chloride.

Storage conditions

Store below 30°C, protected from light and moisture; keep out of reach of children.

Sodium Bicarbonate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.