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At a glance

Zaleplone is a prescription medicine used to treat insomnia. It reduces sleep onset time and frequent awakening at night. This medicine improves sleep maintenance and therefore ensures sound sleep.

Indications
  • Insomnia
Pharmacology

Zaleplon, a pyrazolopyrimidine, is a sedative and hypnotic agent structurally unrelated to the benzodiazepines and other sedative-hypnotic agents. It is shown to interact with GABA subtype A complex by binding selectively to benzodiazepine type 1 receptor.

Dosage

Adult Dose (Oral):

  • Insomnia: 5-10 mg before bedtime; max 20 mg daily
  • Elderly (>65 yr): 5 mg before bedtime; max 10 mg daily
  • Hepatic impairment: Mild to moderate: 5 mg at bedtime; Severe: Contra-indicated

Renal Impairment: Mild to moderate: no dose adjustment necessary; severe: not studied

Side effects

Common Side Effects:

  • Dizziness
  • Lightheadedness
  • Impaired coordination
  • Paresthesia (tingling or pricking sensation)
Use in pregnancy

Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect ability to drive
  • Best taken without food as a high-fat meal can reduce its absorption and effect
  • Makes you feel dizzy next morning; do not drive or do anything requiring concentration
  • Inform your doctor if your sleep doesn't improve after 7 to 10 days of treatment
  • Do not stop taking medication suddenly as it may lead to anxiety, mood changes, and restlessness
Overdose effects

Symptoms: Limited information.

Treatment: Supportive care.

Storage conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Zaleplone — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.