Sotalex 80

Sotalol Hydrochloride is used to treat various types of serious irregular heartbeat (arrhythmia) such as fibrillation and tachycardia. It is an anti-arrhythmic type of medicine and rapidly restores your heart to a steady and regular rhythm. Sotalol Hydrochloride should be taken as advised by your doctor. It may be taken with or without food. Continuous monitoring of blood pressure and heart rate may be needed while taking this medicine. It is important that you keep taking it until your doctor decides it is safe to stop it. If you stop taking this medicine, you may get dangerous uneven heartbeats, which can be life-threatening. The most common side effects of this medicine include nausea, vomiting, taste change, slow heart rate, and diarrhea. This medicine can also cause problems with your liver, lungs, nerves and thyroid gland. Ask your doctor what signs to look out for and report any symptoms you have. It takes a long time to clear from the body. You may continue to have side effects after you stop using it. Ask your doctor about ways to prevent or reduce them. Before getting this medicine, you should let your doctor know if you have low blood pressure, drink a lot of alcohol or have liver, heart or thyroid problems. You should also inform your doctor about all other medicines that you are taking as many can seriously affect or be affected by this medicine. Some medicines like certain antibiotics and medicines for depression and mental illness should be avoided with this medicine. Pregnant or breastfeeding women should consult their doctor before taking this medicine. Your doctor will carry out regular tests to check your liver and thyroid gland. You may also be advised other blood tests, x-rays, and eye tests both before and during treatment. Sotalol Hydrochloride is an anti-arrhythmic medication. It regulates heart beat by blocking abnormal electrical signals in the heart.

• Arrhythmia

Sotalol is a non-cardioselective beta-blocker. It increases sinus cycle length, slows heart rate, decreases AV nodal conduction and increases AV nodal refractoriness. It also prolongs AV monophasic action potentials. However, it lacks intrinsic sympathomimetic and membrane-stabilising properties.

Adult Dose: Oral Supraventricular and ventricular arrhythmias Adult: Initially, 80 mg/day as single or in 2 divided doses, increased gradually every 2-3 days. Usual dose: 160-320 mg/day in 2 divided doses. Life-threatening ventricular arrhythmias Adult: Initially, 80 mg bid, increased gradually every 3 days to 240-320 mg/day in divided doses if needed. Maintenance: 160-320 mg/day in divided doses. Max: 480-640 mg in divided doses. Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation 30-60 Half the usual dose. 10-30 Quarter the usual dose. <10 Not recommended.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sotalol Hydrochloride may be taken with or without food, but it is better to take it at a fixed time. Avoid Sotalol Hydrochloride with dairy products such as milk, cheese, curd, butter, paneer and ice cream.

If you miss a dose of Sotalol Hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Dizziness • Fatigue • Slow heart rate • Breathlessness • Weakness

[UNSAFE] Sotalol Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Your doctor may get regular blood tests done to monitor sodium and potassium level, blood sugar level, kidney function, and lung function while you are taking this medicine. Notify your doctor if you have any heart or kidney problem. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Please remind your doctor you are taking this medicine every time you visit him and ask him if the medicine can be stopped.

Bronchial asthma or history of COPD, sick sinus syndrome, symptomatic sinus bradycardia, cardiogenic shock. 2nd and 3rd degree AV block, untreated phaeochromocytoma, torsades de pointes, congenital or acquired long QT syndromes, uncontrolled cardiac failure, cardiogenic shock, metabolic acidosis, hypotension, severe peripheral arterial disease, Raynaud's disease, anaesthesia that causes myocardial depression. Renal impairment (CrCl <10 mL/min). Concomitant use w/ Ca channel blockers (e.g. verapamil and diltiazem).

May increase risk of bradycardia w/ digoxin. May increase risk of arrhythmias w/ diuretics. May potentiate rebound HTN w/ clonidine. May prolong refractoriness w/ disopyramide, quinidine, procainamide, amiodarone and bepridil. May prolong QT interval w/ TCAs, phenothiazines, terfenadine and astemizole. Increased risk of torsades de pointes w/ K-depleting diuretics, erythromycin IV, halofantrine, pentamidine, and quinolones. May prolong neuromuscular blockade of tubocurarine. May reduce response to insulin and oral hypoglycaemics. Potentially Fatal: Additive effect on AV conduction and ventricular function w/ verapamil and diltiazem.

[UNSAFE] It is unsafe to consume alcohol with Sotalol Hydrochloride.

[SAFE IF PRESCRIBED] Sotalol Hydrochloride is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[CONSULT YOUR DOCTOR] Sotalol Hydrochloride is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Sotalol Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Sotalol Hydrochloride may be needed. Please consult your doctor. Use of Sotalol Hydrochloride is not recommended in patients with serious kidney disease. [SAFE IF PRESCRIBED] Sotalol Hydrochloride is safe to use in patients with liver disease. No dose adjustment of Sotalol Hydrochloride is recommended.

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