Spusoft 300

• Respiratory tract disorders: Used in the treatment of various respiratory diseases associated with viscid mucus, including acute and chronic bronchitis.

Erdosteine is a prodrug that is metabolised into N-thiodiglycolyl-homocysteine whereby free thiol groups are formed leading to the opening of the disulphide bonds of the bronchial mucoproteins, thus reducing the viscosity of mucus and purulent sputum. It also antagonises the local formation of free radicals and inhibits elastase enzyme activity and bacterial adhesion to epithelial cells.

Adult Dose:

• Mucolytic: 300 mg bid; Max duration: 10 days.
• Chronic cases: May be given up to 12 months as directed by physician.
• Mild hepatic impairment: Max: 300 mg daily.
• Severe hepatic impairment: Not recommended.

Renal Dose: CrCl <25 mL/min: Contraindicated.

Common Side Effects:

• Flushing (sense of warmth in the face, ears, neck and trunk)
• Increased sweating
• Nausea
• Vertigo
• Vomiting
• Epigastric pain

Other Side Effects:

• Headache
• Cold
• Taste alterations
• Diarrhea
• Angioedema
• Skin allergic reactions

Use in Pregnancy: Information regarding the use of Erdosteine during pregnancy is not available. Consult your doctor.

Precautions:

• Erdosteine does not usually affect your ability to drive.
• It helps in thinning and removal of mucus from the airways.
• Your doctor may check your liver functions before starting.
• Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
• Inform your doctor if you have any stomach or kidney problem.
• In mild liver failure, do not exceed a dose of 300 mg per day.

Overdose: Limited information is available on overdose. In case of overdose, symptomatic treatment should be given and seek immediate medical attention.

Storage: Keep in a dry place away from light and heat. Keep out of reach of children.