৳ 5/unit
Pack: ৳ 5
৳ 5/unit
Pack: ৳ 5
At a glance
Pentazocine Hydrochloride is an opioid analgesic used for the relief of moderate to severe pain. It may also be used for preoperative or preanesthetic medication and as a supplement to surgical anesthesia.
Indications
- Moderate to severe pain
- Preoperative or preanesthetic medication
- Supplement to surgical anesthesia
- Labor pain
Pharmacology
Pentazocine is a benzomorphan derivative with mixed opioid agonist and antagonist actions. It alters perception of and response to pain and produces generalized CNS depression by binding to opiate receptors in the CNS and acting as a partial agonist/antagonist.
Dosage
Adult Dose:
- Oral (Moderate to severe pain): 50-100 mg every 3-4 hours; max 600 mg/day
- IV/IM/SC (Anesthesia & pain): 30 mg every 3-4 hours; max 360 mg/day; doses >30 mg IV or 60 mg IM/SC not recommended
- Labor pain: 30 mg IM once OR 20 mg IV, 2-3 times at 2-3 hour intervals
- Renal impairment: CrCl 10-50: 75% normal dose; CrCl <10: 50% normal dose
- Hepatic impairment: Reduce dose or avoid in liver disease
Pediatric Dose (>1 year):
- Oral (6-12 years): 25 mg every 3-4 hours
- IM: 0.5 mg/kg
Side effects
Common Side Effects:
- Nausea
- Dizziness or light-headedness
- Vomiting
- Euphoria
- Headache
- Drowsiness
- Fatigue
- Constipation
- Dry mouth
- Increased sweating
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects. Pregnancy Category C.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May impair driving ability; do not drive if drowsy or dizzy
- Avoid alcohol (may cause excessive sleepiness)
- Caution and low dosage in respiratory depression
- Caution in renal or hepatic impairment
- Caution in patients prone to seizures (seizures may occur)
- Withdrawal symptoms may occur in opioid-dependent patients
Overdose effects
Clinical experience with overdosage is insufficient. Treatment: Oxygen, IV fluids, vasopressors, supportive measures; for respiratory depression, parenteral naloxone is a specific and effective antagonist.
Storage conditions
Keep away from light and store below 25°C; do not freeze; keep out of reach of children.