৳ 4.40/unit
Pack: ৳ 4.40
৳ 4.40/unit
Pack: ৳ 4.40
At a glance
Pyrimethamine + Sulfadoxine is a combination medicine used for the treatment of malaria. Pyrimethamine is an antiparasitic that increases haeme levels toxic to the malaria parasite, and Sulfadoxine is an antibiotic that stops bacterial folic acid production.
Indications
- Malaria
Pharmacology
Pyrimethamine inhibits parasitic dihydrofolate reductase, preventing tetrahydrofolic acid synthesis. Sulfadoxine inhibits dihydropteroate synthetase by competing with para-aminobenzoic acid, preventing folic acid production. This combination provides synergistic effects against malaria parasites.
Dosage
Adult Dose (Oral):
- Malaria: 3 tablets (each containing 25 mg pyrimethamine + 500 mg sulfadoxine) as a single dose
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Feeling of fullness
- Dizziness
- Headache
- Mouth sore
- Skin rash
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if dizzy or drowsy
- Avoid alcohol (excessive drowsiness)
- Caution in kidney and liver disease
- Caution in pregnancy and lactation
Overdose effects
Overdose: Nausea, vomiting, headache, skin reactions, blood dyscrasias; treatment: symptomatic supportive care, gastric lavage.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.