osudhkosh
New
Company•Incepta Pharmaceuticals Ltd.

Sunicent

50mgRx
Generic: Sunitinib

৳ 1,000/unit

Pack: ৳ 12,000

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At a glance

Sunitinib is a multi-tyrosine kinase inhibitor used for gastrointestinal stromal tumor (GIST), advanced renal cell carcinoma (RCC), and pancreatic neuroendocrine tumors (pNET).

Indications
  • Gastrointestinal stromal tumor (GIST) – after progression on or intolerance to imatinib
  • Advanced renal cell carcinoma (RCC)
  • Adjuvant treatment of RCC (high risk after nephrectomy)
  • Advanced pancreatic neuroendocrine tumors (pNET)
Pharmacology

Sunitinib inhibits multiple receptor tyrosine kinases including PDGFR, VEGFR, KIT, FLT3, CSF-1R, and RET. It blocks signaling pathways involved in tumor cell proliferation, angiogenesis, and metastasis, reducing tumor growth and promoting apoptosis.

Dosage

Adult Dose (Oral):

  • GIST/Advanced RCC: 50 mg once daily (4 weeks on, 2 weeks off – 4/2 schedule)
  • Adjuvant RCC: 50 mg once daily (4/2 schedule) – nine 6-week cycles
  • pNET: 37.5 mg once daily continuously (no scheduled off period)
Side effects

Common Side Effects:

  • Nausea, vomiting, weakness
  • Diarrhea, constipation
  • Hypertension
  • Skin discoloration, hair discoloration
  • Painful blisters on hands and feet
  • Fatigue, fever, loss of appetite, weight loss
Use in pregnancy

Use in Pregnancy: Unsafe; evidence of fetal risk; use only in life-threatening situations; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Hepatotoxicity: Monitor liver enzymes
  • Cardiovascular events, QT prolongation
  • Hypertension: Regular monitoring
  • Hemorrhage, thrombotic microangiopathy
  • Thyroid dysfunction: Regular monitoring
  • Hypoglycemia: Caution in diabetic patients
  • Wound healing delay: Discontinue before surgery
Overdose effects

No specific antidote for overdose; provide supportive care; if indicated, eliminate unabsorbed drug by emesis or gastric lavage; overdose up to 1500 mg has been reported without adverse reactions.

Storage conditions

Store at 25°C in a cool and dry place, protected from light; keep out of reach of children.

Sunitinib — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.