oshudhkosh

Tamoxen10mg

Rx
Generic:
Tamoxifen
Dosage form:
Tablet
Pack size:
Tablet

৳ 10/unit

Pack: ৳ 10

At a glance

Tamoxifen — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Tamoxifen is an anti-estrogens. It is used in the treatment of breast cancer. It is also used to reduce the risk of breast cancer in women with a high chance of developing it. This medicine helps to slow down the growth and multiplication of cancer cells. Tamoxifen is also helpful in the treatment of infertility. It can be taken with or without food, but take it at the same time to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include nausea, skin rash, hot flushes, thinning of hair and tiredness. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some side effects may mean you should inform your doctor immediately include vaginal bleeding, irregular menstrual period and vaginal discharge. It makes birth control pills less effective, hence use a condom and other preventive measures to avoid pregnancy. Before taking this medicine, tell your doctor if you are on treatment of infertility or had a blood clot disorder. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. Your doctor may perform some blood tests to check liver function and calcium level in the body. Tamoxifen is a hormone-based medication. It works by binding to estrogen receptors and blocking the effects of estrogen (a natural female hormone) in the breast tissue. This slows down the growth and multiplication of breast cancer cells.

Indications

• Breast cancer

Mechanism of action

Tamoxifen, a triphenylethylene derivative, produces a nuclear complex by competitively binding to oestrogen receptors on tumours and other tissue targets thus, decreasing DNA synthesis and inhibiting oestrogen effect. It is only cytostatic rather than cytotoxic due to accumulation of cell in G0 and G1 phases.

Dosage

Adult Dose: Oral Breast Cancer Treatment 20 mg daily as a single or in 2 divided doses. Max: 40 mg daily. Continue with adjuvant therapy for at least 5 years For women with ER-positive disease, continuing tamoxifen to 10 years rather than stopping at 5 years produces a further reduction in recurrence and mortality, particularly after year 10 Breast Cancer Prevention Indicated to reduce the incidence of breast cancer in women at high risk for breast cancer; high risk is defined as women aged >35 years with a 5-year predicted risk of breast cancer >1.67% (calculated by the Gail Model) Adult: 20 mg daily for 5 yr. Data are limited for use >5 yr in the risk-reduction setting Anovulatory infertility Adult: 20 mg daily on days 2-5 of the menstrual cycle, increase if necessary in subsequent cycles. Max: 80 mg daily. Women w/ irregular menstruation: Initial course may begin on any day and a 2nd course may start 45 days later.

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tamoxifen may be taken with or without food, but it is better to take it at a fixed time.

Side effects

Common: • Nausea • Skin rash • Hot flashes • Thinning of hair • Vaginal discharge • Swelling

Precautions & warnings

[UNSAFE] Tamoxifen may cause side effects which could affect your ability to drive. Tamoxifen may cause tiredness. This may affect your driving ability. Tamoxifen helps treat breast cancer. It also reduces the risk of cancer coming back and of getting cancer in the other breast. Use a reliable barrier contraceptive method (such as condoms) to prevent pregnancy while you are taking this medicine and for 2 months after you stop taking it. Inform your doctor if you are pregnant, planning to conceive or breastfeeding. Inform your doctor if your periods become irregular, especially if associated with heavier bleeding. Do not stop taking the medicine without talking to your doctor first.

Contraindications

History of DVT or pulmonary embolism. Pregnancy and lactation. Concomitant coumarin-type anticoagulant therapy.

Drug interactions

Increases dopaminergic effect of bromocriptine. Increased risk of thromboembolic events w/ cytotoxic drugs. Increased risk of bleeding w/ platelet aggregation inhibitors. May mutually reduce effects w/ hormone preparations particularly oestrogens (e.g. OCs). Reduced plasma levels w/ CYP3A4 inducers (e.g rifampicin) and CYP2D6 inhibitors. Increased plasma levels w/ CYP3A4 inhibitors. Potentially Fatal: Significant increase in anticoagulant effect w/ coumarin-type anticoagulants (e.g. warfarin).

Food interactions

[UNSAFE] It is unsafe to consume alcohol with Tamoxifen.

Use in pregnancy

[UNSAFE] Tamoxifen is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Use in lactation

[CONSULT YOUR DOCTOR] Tamoxifen is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Renal / hepatic impairment

[SAFE IF PRESCRIBED] Tamoxifen is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Tamoxifen may not be needed in these patients. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Tamoxifen in patients with liver disease. Please consult your doctor.

Common questions

If any symtom of brest cancer if have whats the cure First is confirmation of breast cancerChance of cure depends on stage of cancer BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON. Metastatic breast cancer, send me previous treatment details I am PATIENT have pain in my breastes and feel very weight before one week of my menstrual perieds date Is it any symptoms of breast cancer ? Need your advice And also having back pain during menstrual dates please give your valubel advice No it's not a symptom of breast cancer. How to diagonise breast cancer? It should be diagnosed by mammogram and biopsy left breast cancer had amplated Please write complete information She has breast cancer at 4 sta Dear PATIENT 4 Breast Cancer means that the cancer has spread to other parts of the body. The management of such cancers depends on the site where the cancer has spread and on the receptor status of the breast cancer. If you can share the details with me, I will be happy to let you know the potential management Can a hard mass in the breast be a breast cancer? It can be benign also, u can get examined by doctorHowever at age of 20 to 25 less likely to be cancer

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.