Tapexia 50

• Moderate to severe pain

Adult Dose: Oral Moderate to severe acute pain Adult: Initially, 50 mg, 75 mg or 100 mg 4-6 hrly, depending on pain intensity. On day 1, a 2nd dose may be given 1 hr after the initial dose if pain relief is inadequate; subsequent dose may be given 4-6 hrly, adjust according to response. Max: 700 mg on day 1, 600 mg daily on subsequent days. Elderly: Initiate dosage at lower end of range Hepatic impairment Mild: Dosage adjustment not required Moderate: 50 mg q8hr initially; dosing frequency not to exceed 3 times daily; Severe: Not recommended Child Dose: Safety and efficacy not established Renal Dose: Renal impairment CrCl >30 mL/min : Dosage adjustment not required CrCl <30 mL/min: Not recommended

Common: • Nausea • Sleepiness • Vomiting • Dizziness

[CONSULT YOUR DOCTOR] Tapentadol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[UNSAFE] Tapentadol may cause side effects which could affect your ability to drive. If you feel drowsy, dizzy, have blurred vision or a slow reaction time while taking Tapentadol, then do not drive. Tapentadol is a strong painkiller which is used in the treatment of moderate to severe pain when other treatments do not treat your pain well enough or you cannot tolerate them. The addiction / habit-forming potential of Tapentadol is very high. Take exactly as prescribed by your doctor. Use caution while driving or doing anything that requires concentration as Tapentadol can cause dizziness and sleepiness. While taking this medication, avoid alcohol in all forms including beer, wine, aftershave lotions, mouthwash, vinegar, certain desserts, colognes, and liquid medications. Inform your doctor if you have asthma, liver, kidney or pancreatic disease, or are severely constipated.